700325 | 3β,5α,6β-trihydroxycholanoic acid

Trihydroxy Cholic Acid - 3β,5α,6β-trihydroxycholanoic acid

3β,5α,6β-trihydroxycholanoic acid

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3β,5α,6β-trihydroxycholanoic acid

Trihydroxy Cholic Acid - 3β,5α,6β-trihydroxycholanoic acid

Trihydroxy cholic acid is a bile acid (BA), a product of a multistep metabolic pathway.

Bile acids are amphipathic steroid molecules found in the bile of mammals. They are derived from cholesterol oxidation in the liver. BAs facilitate the metabolism (digestion, absorption, excretion, and transport) of fatty acids, vitamins, and other sterols in the liver and the intestines.

Trihydroxy bile acid is synthesized from primary compounds like cholestan-5,6-epoxide (5,6-EC) and cholestane-3β,5α,6β-triol (3β,5α,6β-triol) in a reaction, induced by cholesterol hydrolases following a formation through free radical forms. Afterward, these compounds enter into new branches of the bile acid biosynthesis pathways, forming derivatives, including trihydroxy cholic bile acid.

The intermediate metabolites formed in these pathways are believed to have diagnostic value for different diseases affecting the organism’s ability to metabolize fats within cells: Niemann Pick types B and C and lysosomal acid lipase deficiency.

Furthermore, these unusual molecules like Trihydroxy cholic acid are not only markers of pathologic conditions, but provide clues towards causes and treatment, as well.

A reliable approach to investigate Trihydroxy cholic acid and other similar metabolites is enzyme-assisted derivatization using electrospray ionization-mass spectrometry.

Avanti Polar Lipids Trihydroxy cholic acid is suitable for a broad range of experimental applications.

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula

C24H40O5

Percent Composition

C 70.55%, H 9.87%, O 19.58%

Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
16030-92-5
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
408.58
Exact Mass
408.29
Certificates of Analysis

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