700268 | Glycolithocholic acid

5β-cholanic acid-3α-ol N-(carboxymethyl)-amide

Glycolithocholic acid

Powder

Size SKU Packaging Price
10mg 700268P-10mg 700268P-10mg 1 x 10mg $163.80
Request Bulk Pricing

Info

Glycolithocholic acid

5β-cholanic acid-3α-ol N-(carboxymethyl)-amide

Glycolithocholic Acid (Lithocholylglycine / Glycolithocholate) is a natural endogenous metabolite and the glycine conjugated form of the bile acid (BA) lithocholic acid. It’s also an acyl glycine.

Lithocholic acid is one of the secondary BAs and derives from the primary BA chenodeoxycholic acid under the effect of bacterial action in the colon. It’s one of the most toxic BAs and is able to induce cholestatic liver damage. Lithocholic acid and other secondary and primary BAs undergo a process of conjugation with the amino acids glycine or taurine in liver hepatocytes. It’s the same mechanism whereby Glycolithocholic Acid is obtained.

Glycholithocholic Acid’s main application is to serve as a predictive marker in the diagnosis of ulcerative colitis, primary sclerosing cholangitis, and non-alcoholic steatohepatitis.

The glycine conjugate is increased in the liver of rats on a diet supplemented with ursodeoxycholic acid. Whereas, its plasma concentrations are reduced after subcutaneous administration of PEG-obestatin - a modified peptide hormone.

Serum Glycolithocholic Acid levels are observed to physiologically rise with age in children.

Avanti Polar Lipids’ high-standard Glycolithocholic Acid compound is a pure and stable product to use in a broad range of studies.

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula

C26H43NO4

Percent Composition

C 72.02%, H 10.00%, N 3.23%, O 14.76%

Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
474-74-8
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
433.63
Exact Mass
433.32
Certificates of Analysis

Related Products

700335
Glycoallolithocholanoic acid Glycoallolithocholanoic acid Buy Now
700339
Glyco-ω-muricholanoic acid Glyco-ω-muricholanoic acid Buy Now
700311
Glyco-3ß,5α,6ß -trihydroxycholanoic acid (NPCBA2) Glyco-3ß,5α,6ß -trihydroxycholanoic acid (NPCBA2) Buy Now
700336
Glycoisolithocholanoic acid Glycoisolithocholanoic acid Buy Now

Cart

Item Price Qty.
${ item.sku }
Base Price: $${ (item.price - (item.options.custompackaging * 4.2 + (item.options.custompackaging > 50 ? 250 : 150))).toFixed(2) }
Custom Packaging: +${ (item.options.custompackaging * 4.2 + (item.options.custompackaging > 50 ? 250 : 150)).toFixed(2) }

Change Custom Packaging
$ ${ item.total.toFixed(2) }
Subtotal: ${ cart.itemSubtotal|money }
${ adjustment.name } ${ adjustment.amountAsCurrency }
Order Total: ${ cart.totalPriceAsCurrency }