700251 | Taurocholic acid, sodium salt

5β-cholanic acid-3α,7α,12α-triol N-(2-sulphoethyl)-amide, sodium salt

Taurocholic acid, sodium salt

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Taurocholic acid, sodium salt

5β-cholanic acid-3α,7α,12α-triol N-(2-sulphoethyl)-amide, sodium salt

Taurocholic Acid (TCA), also known as cholanic acid, cholyltaurine, taurocholate, or acidum chlatauricum, is a bile acid (BA), involved in the emulsification of fats. It’s one of the many physiological molecules in the body that have cholesterol as its precursor.

The compound occurs naturally as a sodium salt and is a major ingredient in the bile of mammals and carnivorous animals. It’s obtained through a process of conjugation of the primary BA cholic acid with the amino acid taurine. Cholic acid is one of the two main BAs in humans, along with chenodeoxycholic acid.

Taurocholic Acid is found to be a biomarker of the progression of liver cirrhosis and an active promoting factor. It most likely promotes liver cirrhosis by triggering hepatic stellate cells by stimulating the expression of TLR4 - a transmembrane protein, involved in a range of pathological responses and pathways in the body. Thus, recently, TCA has been investigated as a potential therapeutic target for the prevention and treatment of liver cirrhosis.

In addition, serum levels of the tauro-derivative are found to be decreased in Crohn's disease and ulcerative colitis with no extraintestinal manifestations. However, its concentrations are elevated in patients with ulcerative colitis combined with hepatobiliary disease.

Avanti Polar Lipids manufactures quality and pure Taurocholic Acid for experimental bile acid analytical research.

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula

C26H44NNaO7S

Percent Composition

C 58.08%, H 8.25%, N 2.61%, Na 4.28%, O 20.83%, S 5.96%

Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
145-42-6
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
537.69
Exact Mass
537.27
Certificates of Analysis

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