700248 | Taurohyodeoxycholic acid, sodium salt

5β-cholanic acid-3a,6a-diol N-(2-sulphoethyl)-amide, sodium salt


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Taurohyodeoxycholic acid, sodium salt

Taurohyodeoxycholic acid, sodium salt

5β-cholanic acid-3a,6a-diol N-(2-sulphoethyl)-amide, sodium salt

Taurohyodeoxycholic Acid (THDCA) is a steroid metabolite and the taurine-conjugated variation of the natural bile acid (BA) hyodeoxycholic acid.

Hyodeoxycholic acid is obtained from the primary BA cholic acid and belongs to the group of 5β-cholanoic acids. It has a role as a human and a mouse metabolite.

Taurohyodeoxycholic Acid is predominantly found in humans and pigs, but is also present in other animal species.

Its steroid structure is due to the presence of two hydroxy groups: 3α and 6α. As a result, the molecules of THDCA have a hydrophobic-hydrophilic balance, which makes it similar to tauroursodeoxycholic acid (TUDCA). The physicochemical properties of THDCA in terms of lipophilicity and critical micellar concentration resemble those of TUDCA. Therefore, THDCA has been proposed to serve as an alternative to TUDCA and other BAs in the treatment of cholesterol gallstones dissolution. Additionally, THDCA is stable to intestinal microbiota metabolism and this is another potential advantage, compared to other BAs.

Taurohyodeoxycholic Acid is also thought to stimulate bile flow and biliary cholesterol and lipid secretion limits myeloperoxidase activity and expression of TNF-α and IL-6, and reduces colonic damage in models of ulcerative colitis.

Avanti’s quality Taurohyodeoxycholic Acid is suitable for a broad range of preclinical studies in the field of lipid activity and functions.

Hygroscopic
No
Light Sensitive
No
Molecular Formula

C26H44NNaO6S

Percent Composition

C 59.86%, H 8.50%, N 2.68%, Na 4.41%, O 18.40%, S 6.15%

Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
38411-85-7
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
521.690
Exact Mass
521.690