700244 | Tauro-ß-muricholic acid, sodium salt

5ß-cholanic acid-3α,6ß,7ß-triol N-(2-sulphoethyl)-amide, sodium salt


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Tauro-ß-muricholic acid, sodium salt

Tauro-ß-muricholic acid, sodium salt

5ß-cholanic acid-3α,6ß,7ß-triol N-(2-sulphoethyl)-amide, sodium salt

Tauro-β-Muricholic Acid is an endogenous steroid metabolite, released from the liver in human and rat organisms.

The compound is derived from the bile acid (BA) β-muricholic acid through an enzyme-regulated process of conjugation between the BA and the amino acid taurine. β-Muricholic acid is a member of the group of muricholic acids and its hydroxy groups at positions 6 and 7 have β-configuration.

Tauro-β-Muricholic Acid is most commonly used as an experimental metabolite in cholestasis research.

The compound, together with other taurine-conjugated forms of muricholic acids, is also believed to be a reversible and competitive antagonist of the Farnesoid X receptor (FXR).

Farnesoid X receptor belongs to the superfamily of nuclear receptors and has an important role as a molecule that contributes to the physiological occurrence of different metabolic reactions. It’s related to BA metabolism and homeostasis and is activated by BAs at the same time.

Hence, Tauro-β-Muricholic Acid can be implied as a detergent in experimental work concerning FXR properties and potential effects in the treatment of certain conditions.

The taurine conjugate is also considered to increase concentrations of serum cytokines, including IL-6, IL-17, and IFN-γ.

Rely on Avanti Polar Lipids to provide you with a highly pure and stable Tauro-β-Muricholic Acid research product for quality experimental development.

Hygroscopic
No
Light Sensitive
No
Molecular Formula

C26H44NNaO7S

Percent Composition

C 58.08%, H 8.25%, N 2.61%, Na 4.28%, O 20.83%, S 5.96%

Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
145022-92-0
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
537.690
Exact Mass
537.270