700243 | Tauro-α-muricholic acid, sodium salt

5ß-cholanic acid-3α,6ß,7α-triol N-(2-sulphoethyl)-amide, sodium salt


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Tauro-α-muricholic acid, sodium salt

Tauro-α-muricholic acid, sodium salt

5ß-cholanic acid-3α,6ß,7α-triol N-(2-sulphoethyl)-amide, sodium salt

Tauro-α-Muricholic Acid is a taurine-conjugated form of bile acid (BA), α-muricholic acid, and a rodent metabolite, present in low concentrations in human serum.

α-Muricholic acid is included in the class of muricholic acids in which the hydroxy groups at positions 6 and 7 have respectively β- and α-configuration.

Tauro-α-Muricholic Acid is known to be a reversible and competitive antagonist of the Farnesoid X receptor (FXR).

The Farnesoid X receptor is a part of the nuclear receptor superfamily and has been proven to play a key role in the regulation of a wide range of metabolic pathways. FXR is activated by BAs and actually modulates their synthesis, conjugation, and secretion. The receptor also participates in the control of other lipids and glucose homeostasis and metabolism.

Therefore, Tauro-α-Muricholic Acid can be included in various analyses evaluating FXR activity and potential therapeutic properties.

Tauro-α-Muricholic Acid is also widely used as an experimental detergent in cholestasis studies.

Avanti Polar Lipids offers a broad range of experimental products, including Tauro-α-Muricholic Acid, in support of lipid research. Order here now.

Hygroscopic
No
Light Sensitive
No
Molecular Formula

C26H44NNaO7S

Percent Composition

C 58.08%, H 8.25%, N 2.61%, Na 4.28%, O 20.83%, S 5.96% 

Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
2260905-08-4
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
537.690
Exact Mass
537.270