700123 | CholPC

cholesteryl phosphocholine

CholPC

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25mg 700123P-25mg 700123P-25mg 1 x 25mg $110.00
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Info

CholPC

cholesteryl phosphocholine

Ceramide forms stable, fluid bilayers with cholesteryl phosphocholine, and this formulation has been shown to be more potent than solvent-delivered (DMSO) formulations of C6 Ceramide in inhibiting proliferation, inducing apoptosis, and disturbing calcium homeostasis.

CholPC forms bilayers (giant uni- and multilamellar vesicles, as well as extruded large unilamellar vesicles) with both ceramides and cholesterol. The extruded bilayers appear to be fluid, although highly ordered, even when the ceramide has an N-linked palmitoyl acyl chain.

Data
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C32H58NO4P
Percent Composition
C 69.65%, H 10.59%, N 2.54%, O 11.60%, P 5.61%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
65956-64-1
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
551.781
Exact Mass
551.41
References

Backman APE, Halin J, Kjellberg MA, Mattjus P. Indirect Lipid Transfer Protein Activity Measurements Using Quantification of Glycosphingolipid Production. Methods Mol Biol. 2019;1949:105-114. doi: 10.1007/978-1-4939-9136-5_9. PMID: 30790252.

PubMed ID: 30790252

Sukumaran P, Lönnfors M, Långvik O, Pulli I, Törnquist K, Slotte JP. Complexation of c6-ceramide with cholesteryl phosphocholine - a potent solvent-free ceramide delivery formulation for cells in culture. PLoS One. 2013 Apr 19;8(4):e61290. doi: 10.1371/journal.pone.0061290. PMID: 23620740; PMCID: PMC3631171.

PubMed ID: 23620740

Lönnfors M, Långvik O, Björkbom A, Slotte JP. Cholesteryl phosphocholine--a study on its interactions with ceramides and other membrane lipids. Langmuir. 2013 Feb 19;29(7):2319-29. doi: 10.1021/la3051324. Epub 2013 Feb 4. PMID: 23356741.

PubMed ID: 23356741
Certificates of Analysis

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