700095 | Sitosterol (plant-based, contains 2% of 24α isomer)

Sitosterol (plant-based, contains 2% of 24α isomer)

Info

Sitosterol (plant-based, contains 2% of 24α isomer)

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Sitosterol (synthetic from plant sterol)

Data
Hygroscopic
No
Light Sensitive
No
Solubility in Different Solvents
Soluble in DMSO at 0.1mg/mL, soluble in ethanol and Hexane:Ethyl Acetate (7:3) at 5mg/mL
References

Miyazaki T, Sasaki SI, Toyoda A, Wei FY, Shirai M, Morishita Y, Ikegami T, Tomizawa K, Honda A. Impaired bile acid metabolism with defectives of mitochondrial-tRNA taurine modification and bile acid taurine conjugation in the taurine depleted cats. Sci Rep. 2020 Mar 18;10(1):4915. doi: 10.1038/s41598-020-61821-6. PMID: 32188916; PMCID: PMC7080809.

Patel S, Ashwanikumar N, Robinson E, Xia Y, Mihai C, Griffith JP 3rd, Hou S, Esposito AA, Ketova T, Welsher K, Joyal JL, Almarsson Ö, Sahay G. Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA. Nat Commun. 2020 Feb 20;11(1):983. doi: 10.1038/s41467-020-14527-2. Erratum in: Nat Commun. 2020 Jul 6;11(1):3435. PMID: 32080183; PMCID: PMC7033178.

PubMed ID: 32188916

Kunz S, Matysik S. A comprehensive method to determine sterol species in human faeces by GC-triple quadrupole MS. J Steroid Biochem Mol Biol. 2019 Mar 25;190:99-103. doi: 10.1016/j.jsbmb.2019.03.014. [Epub ahead of print]

PubMed ID: 30923016

Matsuoka K, Nakazawa T, Nakamura A, Honda C, Endo K, Tsukada M. Study of thermodynamic parameters for solubilization of plant sterol and stanol in bile salt micelles. Chem Phys Lipids. 2008 Aug;154(2):87-93. doi: 10.1016/j.chemphyslip.2008.05.002. Epub 2008 May 20.

PubMed ID: 18544343

Fernandez ML, Vega-López S. Efficacy and safety of sitosterol in the management of blood cholesterol levels. Cardiovasc Drug Rev. 2005 Spring;23(1):57-70.

PubMed ID: 15867948

Awad AB, Barta SL, Fink CS, Bradford PG. beta-Sitosterol enhances tamoxifen effectiveness on breast cancer cells by affecting ceramide metabolism. Mol Nutr Food Res. 2008 Apr;52(4):419-26. doi: 10.1002/mnfr.200700222.

PubMed ID: 18338406

Awad AB, Fink CS. Phytosterols as anticancer dietary components: evidence and mechanism of action. J Nutr. 2000 Sep;130(9):2127-30.

PubMed ID: 10958802
Certificates of Analysis

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