700019 | 25-hydroxycholesterol

cholest-5-ene-3ß,25-diol


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Size SKU Packaging Price
5mg 700019P-5mg 700019P-5mg 1 x 5mg $137.00
10mg 700019P-10mg 700019P-10mg 1 x 10mg $215.00
100mg 700019P-100mg 700019P-100mg 1 x 100mg $1,092.00
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25-hydroxycholesterol

25-hydroxycholesterol

cholest-5-ene-3ß,25-diol

Avanti’s unique sterol reverses cataracts in mice. Gestwicki’s team ...... settled on compound 29, a steroid found naturally in the bloodstream but not in the lens, which has no blood supply. Mice with age-related and hereditary cataracts received drops in the right eye, whereas the left eye went untreated. After just a few weeks, the treated eye was visibly clearer, says Gestwicki, who conducted the work while at the University of Michigan. Cataract severity is measured on a scale of zero to four, with four being the worst case. On average, mice in the study had about a one-grade improvement in cataract severity after 4 weeks of treatment. Science DOI: 10.1126/science.aad7400
It has been recently shown that activation of a macrophage toll-like receptor (TLR) by microbial antigens induces synthesis of 25-hydroxycholesterol, and that this oxysterol potently suppresses IgA production (see References). You can find additional information on this compound at the following link:
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C27H46O2
Percent Composition
C 80.54%, H 11.51%, O 7.95%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
2140-46-7
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
402.653
Exact Mass
402.350
Synonyms

110816

Makley, L.N., K.A. McMenimen, B.T. DeVree, J.W. Goldman, B.N. McGlasson, P. Rajagopal, B.M. Dunyak, T.J. McQuade, A.D. Thompson, R. Sunahara, R.E. Klevit, U.P. Andley, and J.E. Gestwicki. (2015). Pharmacological chaperone for alpha-crystallin partially restores transparency in cataract models. Science 350:674-7. [PubMed]

PubMed ID: 26542570

Reboldi, A., E.V. Dang, J.G. McDonald, G. Liang, D.W. Russell, and J.G. Cyster. (2014). Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon. Science 345:679-84. [PubMed]

PubMed ID: 25104388

Cyster, J.G., E.V. Dang, A. Reboldi, and T. Yi. (2014). 25-Hydroxycholesterols in innate and adaptive immunity. Nat Rev Immunol 14:731-43. [PubMed]

PubMed ID: 25324126

Xu, L., Bai, Q., Rodriguez-Agudo, D., Hylemon, P.B., Heuman, D.M., Pandak, W.M., Ren, S. (2010) Regulation of Hepatocyte Lipid Metabolism and Inflammatory Response by 25-Hydroxycholesterol and 25-Hydroxycholesterol-3-sulfate. Lipids. 45:821-32. [PubMed]

PubMed ID: 20700770

Bauman, D.R., Bitmansour, A.D., McDonald, J.G., Thompson, B.M., Liang, G., Russell, D.W. (2009) 25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production. Proc Natl Acad Sci U S A. 106:16764-9. [PubMed]

PubMed ID: 19805370