700019 | 25-hydroxycholesterol

cholest-5-ene-3ß,25-diol


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Size SKU Packaging Price
5mg 700019P-5mg 700019P-5mg 1 x 5mg $137.00
10mg 700019P-10mg 700019P-10mg 1 x 10mg $215.00
100mg 700019P-100mg 700019P-100mg 1 x 100mg $1,092.00
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25-hydroxycholesterol

25-hydroxycholesterol

cholest-5-ene-3ß,25-diol

Avanti’s unique sterol reverses cataracts in mice. Gestwicki’s team ...... settled on compound 29, a steroid found naturally in the bloodstream but not in the lens, which has no blood supply. Mice with age-related and hereditary cataracts received drops in the right eye, whereas the left eye went untreated. After just a few weeks, the treated eye was visibly clearer, says Gestwicki, who conducted the work while at the University of Michigan. Cataract severity is measured on a scale of zero to four, with four being the worst case. On average, mice in the study had about a one-grade improvement in cataract severity after 4 weeks of treatment. Science DOI: 10.1126/science.aad7400
It has been recently shown that activation of a macrophage toll-like receptor (TLR) by microbial antigens induces synthesis of 25-hydroxycholesterol, and that this oxysterol potently suppresses IgA production (see References). You can find additional information on this compound at the following link:
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C27H46O2
Percent Composition
C 80.54%, H 11.51%, O 7.95%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
2140-46-7
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
402.653
Exact Mass
402.350
Synonyms
<p>110816</p>

Makley, L.N., K.A. McMenimen, B.T. DeVree, J.W. Goldman, B.N. McGlasson, P. Rajagopal, B.M. Dunyak, T.J. McQuade, A.D. Thompson, R. Sunahara, R.E. Klevit, U.P. Andley, and J.E. Gestwicki. (2015). Pharmacological chaperone for alpha-crystallin partially restores transparency in cataract models. Science 350:674-7. [PubMed]

PubMed ID: 26542570

Reboldi, A., E.V. Dang, J.G. McDonald, G. Liang, D.W. Russell, and J.G. Cyster. (2014). Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon. Science 345:679-84. [PubMed]

PubMed ID: 25104388

Cyster, J.G., E.V. Dang, A. Reboldi, and T. Yi. (2014). 25-Hydroxycholesterols in innate and adaptive immunity. Nat Rev Immunol 14:731-43. [PubMed]

PubMed ID: 25324126

Xu, L., Bai, Q., Rodriguez-Agudo, D., Hylemon, P.B., Heuman, D.M., Pandak, W.M., Ren, S. (2010) Regulation of Hepatocyte Lipid Metabolism and Inflammatory Response by 25-Hydroxycholesterol and 25-Hydroxycholesterol-3-sulfate. Lipids. 45:821-32. [PubMed]

PubMed ID: 20700770

Bauman, D.R., Bitmansour, A.D., McDonald, J.G., Thompson, B.M., Liang, G., Russell, D.W. (2009) 25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production. Proc Natl Acad Sci U S A. 106:16764-9. [PubMed]

PubMed ID: 19805370