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25-hydroxycholesterol | 700019





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Avanti’s unique sterol reverses cataracts in mice. Gestwicki’s team ...... settled on compound 29, a steroid found naturally in the bloodstream but not in the lens, which has no blood supply. Mice with age-related and hereditary cataracts received drops in the right eye, whereas the left eye went untreated. After just a few weeks, the treated eye was visibly clearer, says Gestwicki, who conducted the work while at the University of Michigan. Cataract severity is measured on a scale of zero to four, with four being the worst case. On average, mice in the study had about a one-grade improvement in cataract severity after 4 weeks of treatment. Science DOI: 10.1126/science.aad7400
It has been recently shown that activation of a macrophage toll-like receptor (TLR) by microbial antigens induces synthesis of 25-hydroxycholesterol, and that this oxysterol potently suppresses IgA production (see References). You can find additional information on this compound at the following link:
Molecular Formula
Percent Composition
C 80.54%, H 11.51%, O 7.95%
1 Year
CAS Number
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
Exact Mass
GIF Graphics File. 
GIF Graphics File. 
MDL Molfile. 
CDX File. 
Makley, L.N., K.A. McMenimen, B.T. DeVree, J.W. Goldman, B.N. McGlasson, P. Rajagopal, B.M. Dunyak, T.J. McQuade, A.D. Thompson, R. Sunahara, R.E. Klevit, U.P. Andley, and J.E. Gestwicki. (2015). Pharmacological chaperone for alpha-crystallin partially restores transparency in cataract models.  Science 350:674-7. [PubMed]Reboldi, A., E.V. Dang, J.G. McDonald, G. Liang, D.W. Russell, and J.G. Cyster. (2014). Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation  downstream of type I interferon.  Science 345:679-84. [PubMed]
Cyster, J.G., E.V. Dang, A. Reboldi, and T. Yi. (2014). 25-Hydroxycholesterols in innate and adaptive immunity.  Nat Rev Immunol 14:731-43. [PubMed]
Xu, L., Bai, Q., Rodriguez-Agudo, D., Hylemon, P.B., Heuman, D.M., Pandak, W.M., Ren, S. (2010) Regulation of Hepatocyte Lipid Metabolism and Inflammatory Response by 25-Hydroxycholesterol and 25-Hydroxycholesterol-3-sulfate. Lipids. 45:821-32. [PubMed]
Bauman, D.R., Bitmansour, A.D., McDonald, J.G., Thompson, B.M., Liang, G., Russell, D.W. (2009) 25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production. Proc Natl Acad Sci U S A. 106:16764-9. [PubMed]