700015 | 7-ketocholesterol

3ß-hydroxy-5-cholestene-7-one

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Size SKU Packaging Price
5mg 700015P-5mg 700015P-5mg 1 x 5mg $90.35
50mg 700015P-50mg 700015P-50mg 1 x 50mg $589.00
100mg 700015P-100mg 700015P-100mg 1 x 100mg $1,051.00
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7-ketocholesterol

7-ketocholesterol

3ß-hydroxy-5-cholestene-7-one

Hygroscopic
No
Light Sensitive
Yes
Molecular Formula
C27H44O2
Percent Composition
C 80.94%, H 11.07%, O 7.99%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
566-28-9
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
400.637
Exact Mass
400.334
Synonyms
7-oxocholesterol
7-oxo-5-cholesten-3ß-ol-7-one
5-cholesten-3ß-ol-7-one
3ß-hydroxycholest-5-en-7-one
110806

Hutchinson SA, Lianto P, Roberg-Larsen H, Battaglia S, Hughes TA, Thorne JL. ER-Negative Breast Cancer Is Highly Responsive to Cholesterol Metabolite Signalling. Nutrients. 2019 Nov 1;11(11). pii: E2618. doi: 10.3390/nu11112618.

 PubMed ID: 31683867

Rudd-Schmidt JA, Hodel AW, Noori T, Lopez JA, Cho HJ, Verschoor S, Ciccone A, Trapani JA, Hoogenboom BW, Voskoboinik I. Lipid order and charge protect killer T cells from accidental death. Nat Commun. 2019 Nov 27;10(1):5396. doi: 10.1038/s41467-019-13385-x.

 PubMed ID: 31776337

Rossin D, Barbosa-Pereira L, Iaia N, Testa G, Sottero B, Poli G, Zeppa G, Biasi F. A Dietary Mixture of Oxysterols Induces In Vitro Intestinal Inflammation through TLR2/4 Activation: The Protective Effect of Cocoa Bean Shells. Antioxidants (Basel). 2019 May 31;8(6). pii: E151. doi: 10.3390/antiox8060151.

 PubMed ID: 31151323

Fidalgo Rodríguez JL, Dynarowicz-Latka P, Minones Conde J. Interactions of cholesterol and 7‑ketocholesterol with unsaturated fatty acids of different unsaturation degree - The monolayer study. Biochim Biophys Acta Biomembr. 2019 Aug 1;1861(8):1428-1436. doi: 10.1016/j.bbamem.2019.06.002. Epub 2019 Jun 9.

 PubMed ID: 31189076

Tajima N, Xiaoyan L, Taniguchi M, Kato N. 24S-hydroxycholesterol alters activity of large-conductance Ca2+-dependent K+ (slo1 BK) channel through intercalation into plasma membrane. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 May 25. pii: S1388-1981(19)30085-X. doi: 10.1016/j.bbalip.2019.05.010. [Epub ahead of print]

 PubMed ID: 31136842

Rossin D, Dias IHK, Solej M, Milic I, Pitt AR, Iaia N, Scoppapietra L, Devitt A, Nano M, Degiuli M, Volante M, Caccia C, Leoni V, Griffiths HR, Spickett CM, Poli G, Biasi F. Increased production of 27-hydroxycholesterol in human colorectal cancer advanced stage: Possible contribution to cancer cell survival and infiltration. Free Radic Biol Med. 2019 Mar 23;136:35-44. doi: 10.1016/j.freeradbiomed.2019.03.020. [Epub ahead of print]

 PubMed ID: 30910555

Fidalgo Rodríguez JL, Dynarowicz-Latka P, Miñones Conde J. Effects of saturated and polyunsaturated fatty acids on interactions with cholesterol versus 7-ketocholesterol in Langmuir monolayers and their potential biological implications. Colloids Surf B Biointerfaces. 2019 Feb 1;174:189-198. doi: 10.1016/j.colsurfb.2018.08.052. Epub 2018 Aug 25.

 PubMed ID: 30463048

Wang X, Sun J, Zhao XE, Xu Y, Sun L, Zhu S, You J, Wang X. Stable isotope labeling derivatization coupled with magnetic dispersive solid phase extraction for the determination of hydroxyl-containing cholesterol and metabolites by in vivo microdialysis and ultra-high performance liquid chromatography tandem mass spectrometry. J Chromatogr A. 2019 Feb 14. pii: S0021-9673(19)30151-7. doi: 10.1016/j.chroma.2019.02.021. [Epub ahead of print]

 PubMed ID: 30797576