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3D-PHAD® | 699852

Monophosphoryl 3-Deacyl Lipid A (Synthetic)
Pat No. 9,241,988

699852P

Powder

1 mg
$195.00
5 mg
$780.00
10 mg
$1410.00
25 mg
$3000.00

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Vaccination is well-accepted as an effective method to prevent infections by mounting pathogen-specific immune responses prior to the infection. Usually, immunization with vaccine antigens alone is not able to induce robust or long-lasting immune responses — resulting in failure of protective immunity against infections. Thus, adjuvants are required to enhance cellular or humoral immune responses upon immunization. Because vaccine adjuvants using Lipid A have proven to be safe and effective in inducing Th-1 type immune responses to heterologous proteins in animal and human vaccines, Avanti developed Phosphorylated HexaAcyl Disaccharide (PHAD®), the first fully synthetic monophosphoryl Lipid A available for use as an adjuvant in human vaccines.
Stimulatory effect of PHAD® and 3D-PHAD® on macrophages. Macrophage cell line J774 cells were cultured with Avanti PHAD® or 3D-PHAD® for 24hrs. IL-12 levels in supernatants were measured by sandwich ELISA.

Adjuvant Activity

Antigen: gp140 from HIV-1 PHAD®, 3D-PHAD®, and 3D(6A)-PHAD® have been tested extensively in animals using a variety of antigens. In all cases, these adjuvants exhibit a similar activity and safety profile to bacterially-derived MPL. The data above demonstrate the equivalency of the three synthetic adjuvants to the bacterially-derived MPL when presented in a liposomal carrier system (DMPC/DMPG/Cholesterol).
Molecular Formula
C82H158N3O20P
Percent Composition
C 64.07%, H 10.36%, N 2.73%, O 20.82%, P 2.02%
Purity
>99%
Stability
1 Years
Storage
-20°C
CAS Number
1699735-79-9
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
1537.114
Exact Mass
1536.118
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Notes
GIF Graphics File. 
GIF Graphics File. 
MDL Molfile. 
CDX File.