640006 | DMABA-d6 NHS Ester

4-[di(methyl-d3)amino]-2,5-dioxo-1-pyrrolidinyl ester benzoic acid-d6


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DMABA-d6 NHS Ester

DMABA-d6 NHS Ester

4-[di(methyl-d3)amino]-2,5-dioxo-1-pyrrolidinyl ester benzoic acid-d6

The DMABA NHS ester reagents were developed by Dr. Robert Murphy’s laboratory at the University of Colorado in order to create PE derivatives where all subclasses and potentially oxidized products could be universally detected using a common precursor ion in the positive ion mode by Mass Spectrometry.
d4-DMABA Derivatived Brain PE Extract. A. The positive ion electrospray mass spectrum of brain PE lipid extract. B. The NL141 scan of brain PE lipid extract. C. The positive ion electrospray mass spectrum of d4-DMABA derivatized brain PE lipid extract, which is shifted in mass +151 amu when compared with the spectrum of unlabeled brain PE extract. D. P195 amu to selectively detect the d4-DMABA labeled species in the brain PE extract.
Fragmentation of DMABA NHS Ester Reagents. (Described by Berry, et al.)
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C13H8D6N2O4
Percent Composition
C 58.20%, H 7.51%, N 10.44%, O 23.85%
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
CAS Number
1175002-04-6
CAS Registry Number is a Registered Trademark of the American Chemical Society
Molecular Weight
268.298
Exact Mass
268.133
Synonyms
<p>4-(dimethylamino)benzoic acid N-hydroxysuccinimide ester-d6</p>
Zemski Berry, K.A., W.W. Turner, M.S. VanNieuwenhze, and R.C. Murphy. (2009). Stable isotope labeled 4-(dimethylamino)benzoic acid derivatives of glycerophosphoethanolamine lipids. Anal Chem 81:6633-40. [PubMed] Zemski Berry, K.A., W.W. Turner, M.S. VanNieuwenhze, and R.C. Murphy. (2010). Characterization of oxidized phosphatidylethanolamine derived from RAW 264.7 cells using 4-(dimethylamino)benzoic acid derivatives. Eur J Mass Spectrom (Chichester, Eng) 16:463-70. [PubMed] Fruhwirth, G.O., A. Loidl, and A. Hermetter. (2007). Oxidized phospholipids: from molecular properties to disease. Biochim Biophys Acta 1772:718-36. [PubMed] Grimm, M.O., V.J. Haupenthal, T.L. Rothhaar, V.C. Zimmer, S. Grosgen, B. Hundsdorfer, J. Lehmann, H.S. Grimm, and T. Hartmann. (2013). Effect of Different Phospholipids on alpha-Secretase Activity in the Non-Amyloidogenic Pathway of Alzheimer\'s Disease. Int J Mol Sci 14:5879-98. [PubMed] Kosicek, M. and S. Hecimovic. (2013). Phospholipids and Alzheimer's disease: alterations, mechanisms and potential biomarkers. Int J Mol Sci 14:1310-22. [PubMed] Ueda, Y., Y. Kawakami, D. Kunii, H. Okada, M. Azuma, D.S. Le, and S. Yamamoto. (2008). Elevated concentrations of linoleic acid in erythrocyte membrane phospholipids in patients with inflammatory bowel disease. Nutr Res 28:239-44. [PubMed]