640000 | DMABA-d0 NHS Ester

4-(dimethylamino)-2,5-dioxo-1-pyrrolidinyl ester benzoic acid


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DMABA-d0 NHS Ester

DMABA-d0 NHS Ester

4-(dimethylamino)-2,5-dioxo-1-pyrrolidinyl ester benzoic acid

The DMABA NHS ester reagents were developed by Dr. Robert Murphy’s laboratory at the University of Colorado in order to create PE derivatives where all subclasses and potentially oxidized products could be universally detected using a common precursor ion in the positive ion mode by Mass Spectrometry.
d4-DMABA Derivatived Brain PE Extract. A. The positive ion electrospray mass spectrum of brain PE lipid extract. B. The NL141 scan of brain PE lipid extract. C. The positive ion electrospray mass spectrum of d4-DMABA derivatized brain PE lipid extract, which is shifted in mass +151 amu when compared with the spectrum of unlabeled brain PE extract. D. P195 amu to selectively detect the d4-DMABA labeled species in the brain PE extract.
Fragmentation of DMABA NHS Ester Reagents. (Described by Berry, et al.)
Hygroscopic
No
Light Sensitive
No
Molecular Formula
C13H14N2O4
Percent Composition
C 59.54%, H 5.38%, N 10.68%, O 24.40%
Purity
>99%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
58068-85-2
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
262.261
Exact Mass
262.095
Synonyms
<p>4-(dimethylamino)benzoic acid N-hydroxysuccinimide ester-d0</p>

Zemski Berry KA, Turner WW, VanNieuwenhze MS, Murphy RC. Stable isotope labeled 4-(dimethylamino)benzoic acid derivatives of glycerophosphoethanolamine lipids. Anal Chem. 2009 Aug 15;81(16):6633-40. doi: 10.1021/ac900583a. PMID: 20337376; PMCID: PMC2929906.

PubMed ID: 20337376

Zemski Berry KA, Turner WW, VanNieuwenhze MS, Murphy RC. Characterization of oxidized phosphatidylethanolamine derived from RAW 264.7 cells using 4-(dimethylamino)benzoic acid derivatives. Eur J Mass Spectrom (Chichester). 2010;16(3):463-70. doi: 10.1255/ejms.1083. PMID: 20530831; PMCID: PMC3086548.

PubMed ID: 20530831

Fruhwirth GO, Loidl A, Hermetter A. Oxidized phospholipids: from molecular properties to disease. Biochim Biophys Acta. 2007 Jul;1772(7):718-36. doi: 10.1016/j.bbadis.2007.04.009. Epub 2007 May 6. PMID: 17570293.

PubMed ID: 17570293

Kosicek M, Hecimovic S. Phospholipids and Alzheimer's disease: alterations, mechanisms and potential biomarkers. Int J Mol Sci. 2013 Jan 10;14(1):1310-22. doi: 10.3390/ijms14011310. PMID: 23306153; PMCID: PMC3565322.

PubMed ID: 23306153

Ueda Y, Kawakami Y, Kunii D, Okada H, Azuma M, Le DS, Yamamoto S. Elevated concentrations of linoleic acid in erythrocyte membrane phospholipids in patients with inflammatory bowel disease. Nutr Res. 2008 Apr;28(4):239-44. doi: 10.1016/j.nutres.2008.02.005. PMID: 19083414.

PubMed ID: 19083414