Aurora®-DSG | 550001
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- This new conjugate from Avanti consists of an Aurora™ gold cluster capped with triphenylphosphine ligands and a single diglyceride ligand. Fifty-five gold atom nanoparticles, first described by Schmid, are fascinating structures that are commonly used for contrast agents in various imaging applications. Ideally this particle, unlike larger colloidal style particles, is less intrusive to the target application and behaves like an organic entity instead of a foreign metallic probe. They also are a great generic platform for bottom up synthesis of novel, gold-centered nanostructures due to the ease and completeness of ligand exchange reactions. This complex is readily visible under TEM and can also be viewed in optical microscopes if further processed using a silver development procedure.
- Molecular Formula
- 1 Years
- Molecular Weight
- Gold-Lipid Conjugate1,2-distearoyl-sn-glycero-3-(Aurora Nanoparticle)
The controlled injection of nanoscopic objects into living cells with light offers promising prospects for the development of novel molecular delivery strategies or intracellular biosensor applications. Here, we show that single gold nanoparticles from solution can be patterned on the surface of living cells with a continuous wave laser beam. In a second step, we demonstrate how the same particles can then be injected into the cells through a combination of plasmonic heating and optical force. We find that short exposure times are sufficient to perforate the cell membrane and inject the particles into cells with a survival rate of >70%. [Link]
Günter Schmid and Benedetto Corain. Nanoparticulated Gold: Syntheses, Structures, Electronics, and Reactivities. Eur. J. Inorg. Chem. 2003, 3081-3098. [Reference]
Lewandowski, W., K. Jatczak, D. Pociecha, and J. Mieczkowski. (2013). Control of gold nanoparticle superlattice properties via mesogenic ligand architecture. Langmuir 29:3404-10. [PubMed]
Balasubramanian, R., R. Guo, A.J. Mills, and R.W. Murray. (2005). Reaction of Au(55)(PPh(3))(12)Cl(6) with thiols yields thiolate monolayer protected Au(75) clusters. J Am Chem Soc 127:8126-32. [PubMed]
Kojima, C., Y. Hirano, and K. Kono. (2009). Chapter 7 - Preparation of complexes of liposomes with gold nanoparticles. Methods Enzymol 464:131-45. [PubMed]
Murphy, C.J., A.M. Gole, J.W. Stone, P.N. Sisco, A.M. Alkilany, E.C. Goldsmith, and S.C. Baxter. (2008). Gold nanoparticles in biology: beyond toxicity to cellular imaging. Acc Chem Res 41:1721-30. [PubMed]
Marchesano, V., Y. Hernandez, W. Salvenmoser, A. Ambrosone, A. Tino, B. Hobmayer, J. M de la Fuente, and C. Tortiglione. (2013). Imaging inward and outward trafficking of gold nanoparticles in whole animals. ACS Nano 7:2431-42. [PubMed]