360492 | Huzzah® S1P

Human Serum Albumin/Sphingosine-1-Phosphate Complex


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1EA 360492P-1EA 360492P-1EA $270.00
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Huzzah® S1P

Huzzah® S1P

Human Serum Albumin/Sphingosine-1-Phosphate Complex

Avanti’s new HSA lipid delivery system, Huzzah™, improves the cellular delivery of S1P through its conjugation with human serum albumin (HSA), a physiologically relevant carrier protein. This conjugate system eliminates the need for organic solvents, which are well-known to adversely affect viability and the phenotypic characteristics of cells. The Huzzah™ lipid delivery system is supplied as a lyophilized conjugate which can be directly and easily reconstituted in water or a buffer of choice and is ideal for studying the effects of poorly soluble bioactive molecules.
Solubility: Reconstitute lyophilized conjugate in 5 mL of water or other aqueous buffer. This produces a stock solution of 120 - 200 µM sphingosine-1-phosphate*. A short sonication may be necessary to ensure complete dissolution. If necessary, filter sterilize the reconstituted conjugate prior to use in cell culture applications. *Exact concentration will vary from batch to batch. Refer to label for exact product concentration upon reconstitution as determined by mass spectrometric analysis.
Molar Ratio: S1P:albumin (2:1) Albumin Biological Characterization: microbial free; endotoxin < 1 IU/mL Albumin Lipid Characterization: ~0.07g/L phospholipids; ~0.02 g/L sphingolipids; ~0.1 g/L fatty acids; and triglycerides and cholesterols below the limit of quantitation of 0.1 g/L and 0.05 g/L
Hygroscopic
No
Light Sensitive
No
Purity
>99%
Stability
1 Year
Storage Temperature
-20°C
Formula Weight
0.000
Exact Mass
0.000

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PubMed ID: 30427721

Leurs CE, Lopes Pinheiro MA, Wierts L, den Hoedt S, Mulder MT, Eijlers AJC, Schoonheim MM, Balk LJ, Uitdehaag BMJ, Killestein J, de Vries HE. Acid sphingomyelinase: No potential as a biomarker for multiple sclerosis. Mult Scler Relat Disord. 2019 Feb;28:44-49. doi: 10.1016/j.msard.2018.11.024. Epub 2018 Nov 30.

PubMed ID: 30553168

Zhong L, Jiang X, Zhu Z, Qin H, Dinkins MB, Kong JN, Leanhart S, Wang R, Elsherbini A, Bieberich E, Zhao Y, Wang G. Lipid transporter Spns2 promotes microglia pro-inflammatory activation in response to amyloid-beta peptide. Glia. 2019 Mar;67(3):498-511. doi: 10.1002/glia.23558. Epub 2018 Nov 28.

PubMed ID: 30484906