330707 | SPLASH® LIPIDOMIX® Mass Spec Standard

Single-vial Prepared Lipidomic Analytical Standard for Human plasma lipids


Methanol

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1EA 330707-1EA 330707-1EA $468.00
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SPLASH® LIPIDOMIX® Mass Spec Standard

Single-vial Prepared Lipidomic Analytical Standard for Human plasma lipids

Make a splash in your lab and dive right into Lipidomics with our easy to use mixture of deuterium labeled lipids. The SPLASH® Lipidomix® Mass Spec Standard includes all of the major lipid classes at ratios relative to human plasma, allowing one easy internal standard solution to be added to every sample. This internal standard mixture was developed in collaboration with Kim Ekroos (Zora Biosciences).

  • Save time: pre-mixed internal standards
  • Save money: 1 vial is sufficient for 100 plasma samples
  • Exact concentrations provided for quantitative lipidomic analysis
  • Applicable to multiple MS approaches
  • Concentration of each lipid class optimized for plasma analysis
Mixture ComponentsTarget Concentration (µg/mL)
15:0-18:1(d7) PC 160
15:0-18:1(d7) PE    5
15:0-18:1(d7) PS    5
15:0-18:1(d7) PG        30
15:0-18:1(d7) PI  10
15:0-18:1(d7) PA7
18:1(d7) LPC 25
 18:1(d7) LPE   5
18:1(d7) Chol Ester      350
18:1(d7) MG 2
15:0-18:1(d7) DG 10
15:0-18:1(d7)-15:0 TG   55
18:1(d9) SM 30
Cholesterol (d7)       100
Hygroscopic
No
Light Sensitive
No
Stability
1 Year
Storage Temperature
-20°C
Molecular Weight
0.000
Exact Mass
0.000

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PubMed ID: 30872747

Jones JW, Sarkar C, Lipinski MM, Kane MA. Detection and Structural Characterization of Ether Glycerophosphoethanolamine from Cortical Lysosomes Following Traumatic Brain Injury Using UPLC-HDMSE. Proteomics. 2019 Feb 20:e1800297. doi: 10.1002/pmic.201800297. [Epub ahead of Print]

PubMed ID: 30790445

Calderón C, Sanwald C, Schlotterbeck J, Drotleff B, Lämmerhofer M. Comparison of simple monophasic versus classical biphasic extraction protocols for comprehensive UHPLC-MS/MS lipidomic analysis of Hela cells. Anal Chim Acta. 2019 Feb 7;1048:66-74. doi: 10.1016/j.aca.2018.10.035. Epub 2018 Oct 19.

PubMed ID: 30598159

Ferchaud-Roucher V, Kramer A, Silva E, Pantham P, Weintraub ST, Jansson T, Powell TL. A potential role for lysophosphatidylcholine in the delivery of long chain polyunsaturated fatty acids to the fetal circulation. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Mar;1864(3):394-402. doi: 10.1016/j.bbalip.2018.12.007. Epub 2018 Dec 18.

PubMed ID: 30572119

Goyal G, Zheng J, Adam E, Steffes G, Jain M, Klavins K, Hummel T. Sphingolipid-dependent Dscam sorting regulates axon segregation. Nat Commun. 2019 Feb 18;10(1):813. doi: 10.1038/s41467-019-08765-2.

PubMed ID: 30778062

Vale G, Martin SA, Mitsche MA, Thompson BM, Eckert KM, McDonald JG. Three-phase liquid extraction: a simple and fast method for lipidomic workflows. J Lipid Res. 2019 Mar;60(3):694-706. doi: 10.1194/jlr.D090795. Epub 2019 Jan 4.

PubMed ID: 30610084

Garcia D, Hellberg K, Chaix A, Wallace M, Herzig S, Badur MG, Lin T, Shokhirev MN, Pinto AFM, Ross DS, Saghatelian A, Panda S, Dow LE, Metallo CM, Shaw RJ. Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD. Cell Rep. 2019 Jan 2;26(1):192-208.e6. doi: 10.1016/j.celrep.2018.12.036.

PubMed ID: 30605676

Gajenthra Kumar N, Contaifer D Jr, Baker PR, Ekroos K, Jefferson KK, Wijesinghe DS. Untargeted lipidomic analysis to broadly characterize the effects of pathogenic and non-pathogenic staphylococci on mammalian lipids. PLoS One. 2018 Oct 31;13(10):e0206606. doi: 10.1371/journal.pone.0206606. eCollection 2018.

PubMed ID: 30379915

Burla B, Arita M, Arita M, Bendt AK, Cazenave-Gassiot A, Dennis EA, Ekroos K, Han X, Ikeda K, Liebisch G, Lin MK, Loh TP, Meikle PJ, Orešič M, Quehenberger O, Shevchenko A, Torta F, Wakelam MJO, Wheelock CE, Wenk MR. MS-based lipidomics of human blood plasma - a community-initiated position paper to develop accepted guidelines. J Lipid Res. 2018 Aug 16. pii: jlr.S087163. doi: 10.1194/jlr.S087163. [Epub ahead of print]

PubMed ID: 30115755

Holčapek M, Liebisch G, Ekroos K. Lipidomic Analysis. Anal Chem. 2018 Mar 23. doi: 10.1021/acs.analchem.7b05395.

PubMed ID: 29543437

Wall VZ, Barnhart S, Kramer F, Kanter JE, Vivekanandan-Giri A, Pennathur S, Bolego C, Ellis JM, Gijón MA, Wolfgang MJ, Bornfeldt KE. Inflammatory stimuli induce acyl-CoA thioesterase 7 and remodeling of phospholipids containing unsaturated long (≥C20)-acyl chains in macrophages. J Lipid Res. 2017 Jun;58(6):1174-1185. doi: 10.1194/jlr.M076489 (PubMed)

PubMed ID: 28416579