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WR304 mAb-biotinylated | 330022

WR304 Mouse Monoclonal Antibody (IgM), Biotinylated
Anti-(PIP/PIP2)

330022S

Saline

25 μg
$245.00

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WR304 is an antibody that binds specifically to the lipids PIP and PIP2. WR304 also neutralizes infectious HIV-1 virus and can be used to probe the presence of PIP and PIP2 in membranes in a variety of applications including inositol phosphate-dependent cell signaling pathways.
WR304-Biotin allows this antibody to be used in combination with a wide range of commercially available streptavidin-fluorophore and streptavidin-enzyme complexes. WR304-Biotin can also be used with samples that contain mouse IgM.

This antibody was developed by the Walter Reed Army Institute of Research (WRAIR) using a targeted adjuvant protocol with liposomes containing Avanti’s Lipid A.
Purity
>95%
Stability
6 Months
Storage
The recommended long-term storage for WR304 is at -80°C. After initial thawing remaining product should refrozen at -80°C.
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Notes
Wassef, N.M., F. Roerdink, G.M. Swartz Jr, J.A. Lyon, B.J. Berson, and C.R. Alving. (1984). Phosphate-binding specificities of monoclonal antibodies against phosphoinositides in liposomes. Mol Immunol 21:863-8. [PubMed]

Matyas, G.R., Z. Beck, N. Karasavvas, and C.R. Alving. (2009). Lipid binding properties of 4E10, 2F5, and WR304 monoclonal antibodies that neutralize HIV-1. Biochim Biophys Acta 1788:660-5. [PubMed]

Brown, B.K., N. Karasavvas, Z. Beck, G.R. Matyas, D.L. Birx, V.R. Polonis, and C.R. Alving. (2007). Monoclonal antibodies to phosphatidylinositol phosphate neutralize human immunodeficiency virus type 1: role of phosphate-binding subsites. J Virol 81:2087-91. [PubMed]

Beck, Z., N. Karasavvas, J. Tong, G.R. Matyas, M. Rao, and C.R. Alving. (2007). Calcium modulation of monoclonal antibody binding to phosphatidylinositol phosphate. Biochem Biophys Res Commun 354:747-51. [PubMed]