300213 | LNP Lipid Blend 2
LNP Lipid Blend 2
Info
LNP Lipid Blend 2
LNP Lipid Blend 2
This pre-mixed lipid blend is composed of components suitable for producing nucleic acid-based lipid nanoparticles. Works best with DNA/plasmid cargo, and can be used for other nucleic acids as well.
Instructions for using the LNP Lipid Blend 2:
1. Add 1-mL of ethanol to the vial to achieve 25 mg/mL. Mix well to achieve full dissolution.*
2. Dilute nucleic acid in aqueous buffer.**
3. Use solvent injection to create LNPs. Different parameters and cargo will result in different particle size results.
4. Dialyze the final formulation against buffer of choice to remove residual ethanol.
| Catalog Number | Component Name | Mole Fraction |
| 890890 | DOTAP | 49 |
| 700107 | Sitosterol (synthetic from plant sterol) | 38.5 |
| 850365 | DSPC | 11 |
| 880151 | DMG-PEG2000 | 1.5 |
*Note: low heat, sonication, or vortexing can be used as needed
**Note: common buffers include citrate, Tris, or PBS
Data
No
No
3 Months
-20°C
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