131304 | Glucosylceramide (Soy)

Glucocerebrosides (Soy, 98%)


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10mg 131304P-10mg 131304P-10mg 1 x 10mg $154.90
25mg 131304P-25mg 131304P-25mg 1 x 25mg $321.00
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Glucosylceramide (Soy)

Glucosylceramide (Soy)

Glucocerebrosides (Soy, 98%)

Glucosylceramide (GluCer) is a major sphingolipid of plant tissue and, thus, abundant in nature and in dietary food sources. The lipid backbones of mammalian GluCer (sphingosine, d18:1(delta4), and ceramide) induce cell death (apoptosis) and inhibit colon carcinogenesis, it is critical to know the structures of GluCer present in plants as a first step toward understanding this potential link between diet and cancer. This study characterized the molecular species of GluCer from soybean and wheat by low-resolution, high-resolution and tandem mass spectrometry. Soybean GluCer was comprised primarily (>98%) of ceramide with 4,8-sphingadiene (d18:2(delta4,delta8)) and alpha- hydroxypalmitic acid (h16:0); the remainder had the same backbone with h18:0, h20:0, h22:0 and h24:0 fatty acids. Wheat GluCer had three major ceramide, d18:2(delta4,delta8) with h16:0, d18:1(delta8) with h16:0 and d18: 2(delta4,delta8) with h20:0, and smaller amounts of other homologs. These backbones differ from those of mammalian sphingolipids, which often have a delta4-double bond (but rarely a delta8-double bond), and have alpha-hydroxy fatty acids in only some cases. Previously unexplained fragmentations that were diagnostic for the type of sphingoid base backbone (i.e. by homolytic cleavage of the doubly allylic C-6-C-7 bond to yield a stable distonic allylic radical cation and an allylic radical neutral) were also identified. Hence this method should be useful in the identification of double bonds in sphingolipids, and structure-function relationships between sphingolipids and colon carcinogenesis.

Sullards, M.C., D.V. Lynch, A.H. Merrill Jr, and J. Adams. (2000). Structure determination of soybean and wheat glucosylceramides by tandem mass spectrometry. J Mass Spectrom 35:347-53.

Hygroscopic
Yes
Light Sensitive
Yes
Purity
>98%
Stability
1 Years
Storage Temperature
-20°C
CAS Number
497155-61-0
CAS Registry Number is a Registered Trademark of the American Chemical Society
Formula Weight
714.025
Exact Mass
0.000
Synonyms
Cerebroside (Soy)
GlcCer(d18:2/16:0)

Monnier N, Furlan AL, Buchoux S, Deleu M, Dauchez M, Rippa S, Sarazin C. Exploring the Dual Interaction of Natural Rhamnolipids with Plant and Fungal Biomimetic Plasma Membranes through Biophysical Studies. Int J Mol Sci. 2019 Feb 26;20(5). pii: E1009. doi: 10.3390/ijms20051009.

PubMed ID: 30813553

Reisberg M, Arnold N, Porzel A, Neubert RH, Dräger B. Production of Rare Phyto-Ceramides from Abundant Food Plant Residues. J Agric Food Chem. 2017 Mar 1;65(8):1507-1517. doi: 10.1021/acs.jafc.6b04275. Epub 2017 Feb 13.

PubMed ID: 30813553