Sphingolipids - Deuterated

Stable-isotope labeled natural products are commonly used to elucidate structures. The success of the lipidomics field has led to an increase in interest in deuterium-labeled lipids. Deuterated sphingolipids are used in various NMR studies and have been used to determine the carbon-deuterium bond order in the N-acyl chain of sphingomyelin bilayers.

Byun, H. S., & Bittman, R. (2010). Selective deuterium labeling of the sphingoid backbone: facile syntheses of 3,4,5-trideuterio-d-erythro-sphingosine and 3-deuterio-d-erythro-sphingomyelin. Chemistry and physics of lipids, 163(8), 809–813. https://doi.org/10.1016/j.chem...