mPEG Phospholipids

testing

Polymers are often incorporated into liposomes to improve various properties of drug delivery vehicles. Polyethyleneglycol (PEG) is the most commonly used polymer in clinical practice. The methoxy form of PEG (mPEG) is usually used for conjugation applications due to the single hydroxyl group that can be coupled with several other groups including small drugs, proteins, polymers, and lipids. This conjugation results in stealth shielding and increased circulation times. The hydrophilic chains of mPEG conjugated liposomes create a barrier and reduce the interactions that the liposome is able to have with the reticular-endothelial system. In addition, pegylation increases the hydrodynamic size of the drug delivery system and therefore increases the clearance time. PEG-coating of liposomes is generally achieved by using mPEG-phospholipids to generate liposomes known as stealth liposomes (SLs).

Pasut G., Paolino, D., Celia C., Mero A., Jospeh A., Wolfram, J., Cosco D., Schiavon O., Shen H., Fresta M. (2015) Polyethylene glycol (PEG)-dendron phospholipids as innovative constructs for the preparation of super stealth liposomes for anticancer therapy. J. Con. Rel. 199:106-113

  • mPEG 5000
    • BUY
      880200 - 16:0 PEG5000 PE
    • BUY
      880210 - 14:0 PEG5000 PE
    • BUY
      880220 - 18:0 PEG5000 PE
    • BUY
      880230 - 18:1 PEG5000 PE
  • mPEG 3000
    • BUY
      880300 - 16:0 PEG3000 PE
    • BUY
      880310 - 14:0 PEG3000 PE
    • BUY
      880320 - 18:0 PEG3000 PE
    • BUY
      880330 - 18:1 PEG3000 PE
  • mPEG 2000
    • BUY
      880120 - 18:0 PEG2000 PE
    • BUY
      880130 - 18:1 PEG2000 PE
    • BUY
      880150 - 14:0 PEG2000 PE
    • BUY
      880157 - DSPE-PEG2K-triGalNAc
    • BUY
      880160 - 16:0 PEG2000 PE
  • mPEG 1000
    • BUY
      880700 - 16:0 PEG1000 PE
    • BUY
      880710 - 14:0 PEG1000 PE
    • BUY
      880720 - 18:0 PEG1000 PE
    • BUY
      880730 - 18:1 PEG1000 PE
  • mPEG 750
    • BUY
      880600 - 16:0 PEG750 PE
    • BUY
      880610 - 14:0 PEG750 PE
    • BUY
      880620 - 18:0 PEG750 PE
    • BUY
      880630 - 18:1 PEG750 PE
  • mPEG 550
    • BUY
      880500 - 16:0 PEG550 PE
    • BUY
      880510 - 14:0 PEG550 PE
    • BUY
      880520 - 18:0 PEG550 PE
    • BUY
      880530 - 18:1 PEG550 PE
  • mPEG 350
    • BUY
      880400 - 16:0 PEG350 PE
    • BUY
      880410 - 14:0 PEG350 PE
    • BUY
      880420 - 18:0 PEG350 PE
    • BUY
      880430 - 18:1 PEG350 PE