Phosphatidylethanolamine (PE) along with phosphatidylcholine (PC) are the two most abundant glycerophospholipids found in eukaryotes. PE plays a vital role in autophagy, cell division, and protein folding. It is also a precursor used for synthesizing several protein modifications. PE is synthesized by the CDP-ethanolamine branch of the Kennedy pathway. This involves the decarboxylation of phosphatidylserine (PS) and the subsequent base exchange with PS. The acylation of lysophospholipids can also lead to the generation of PE.

Lysophosphatidylethanolamine (LPE) is derived from PE resulting from the partial hydrolysis of PE and the removal of a fatty acid group. It is present as a minor component of cell membranes and plays a role in cell signaling and enzymatic activation.

Farine, L., Niemann, M., Schneider, A. et al. Phosphatidylethanolamine and phosphatidylcholine biosynthesis by the Kennedy pathway occurs at different sites in Trypanosoma brucei. Sci Rep 5, 16787 (2015).