PAHSA

Palmitic acid esters of hydroxystearic acid (PAHSA) are a specific type of a growing class of natural products found in organisms called fatty acid esters of hydroxy fatty acids (FAHFAs). PAHSA regioisomers are of particular interest due to their anti-inflammatory and anti-diabetic effects. Beneficial health effects related to metabolic disorders have been linked to PAHSAs. These beneficial effects include type 1 and type 2 diabetes, colitis, and chronic inflammation. A study conducted in 2020 suggests that 9-PAHSA is a promising non-drug therapy due to its effect on lipotoxicity in steatotic primary hepatocytes and HepG2 cells. This class of compounds offers new hope for the prevention and treatment of many diseases.

Brejchova, K., Balas, L., Paluchova, V., Brezinova, M., Durand, T., Kuda, O. Understanding FAHFAs: From structure to metabolic regulation. Science Direct. https://doi.org/10.1016/j.plipres.2020.101053

Schultz Moreira, A.R.; Rüschenbaum, S.; Schefczyk, S.; Hendgen-Cotta, U.; Rassaf, T.; Broering, R.; Hardtke-Wolenski, M.; Buitrago-Molina, L.E. 9-PAHSA Prevents Mitochondrial Dysfunction and Increases the Viability of Steatotic Hepatocytes. Int. J. Mol. Sci. 2020, 21, 8279.