Diacetylene Lipids

Avanti’s diacetylene lipids are phospholipids with a modified fatty-acid chain containing a conjugated dialkyne moiety. These modified phospholipids fall under the photopolymerizable lipid umbrella and have garnered a lot of attention for their ability to stabilize lipid bilayer structures. Photopolymerizable lipids have also been used to control the permeability of artificial lipid bilayers upon UV-activation. These studies are important for controlled drug delivery, especially related to chemotherapies where the therapeutic agent is highly toxic to cells and tissues.

Watanabe, N.; Nyholm, T.; Slotte, J.; Suga, K.; Umakoshi, H. Solvatochromic Property in Lipid Bilayer Interphase Evaluated from the Deconvolution of Time-Resolved Emission Spectrum of Laurdan. (2018)

Okuno, K.; Saeki, D.; Matsuyama, H. Phase separation behavior of a binary mixture of photopolymerizable diacetylene and unsaturated phospholipids in liposomes. Biochimica et Biophysica Acta (BBA)- Biomembranes. 2020; Vol. 1862.