PAF & PAF Analogs

Platelet-activating factor (PAF) is a class of lipid chemical mediators. PAF is produced by many cells as platelets, neutrophils, monocytes, lymphocytes, basophils, eosinophils, mast cells, and endothelial cells. PAFs play several biological roles both in human pathology and human physiology. Physiological roles of PAF include reproduction, memory, vascular tone, apoptosis, and angiogenesis. Pathological roles of PAF include inflammation, asthma, atherosclerosis, diabetes, renal diseases, cancer, HIV, and periodontitis when found in excess. Inhibition of PAF has been studied as possible treatments for many pathological conditions including anti-inflammation and anti-cancer applications. Initially, PAF only referred to one phosphoglycerylether lipid-containing between 16 and 18 carbons, but now encompasses many PAF-like molecules.

Vasiliki D. Papakonstantinou, Nefeli Lagopati, Effie C. Tsilibary, Constantinos A. Demopoulos, Athanassios I. Philippopoulos, "A Review on Platelet Activating Factor Inhibitors: Could a New Class of Potent Metal-Based Anti-Inflammatory Drugs Induce Anticancer Properties?", Bioinorganic Chemistry and Applications, vol. 2017, Article ID 6947034, 19 pages, 2017.