Cytidine-diphosphate diacylglycerol (CDP-DG) is a precursor for the biosynthesis of many biological phospholipids including PI, PG, and PS. CDP-DG is produced in metabolic pathways through the reaction of cytidine 5’-triphosphate and PA which releases a phosphate group. Various glycerophosphate-based phospholipids are major components of biological membranes. These glycerophosphate-based phospholipids are found in many biological membranes as head-group modified phospholipids including PG, cardiolipin, PE, PS, and PA.

Liu, X., Yin, Y., Wu, J. et al. Structure and mechanism of an intramembrane liponucleotide synthetase central for phospholipid biosynthesis. Nat Commun 5, 4244 (2014).