Inhibitors Of Carnitine Palmitoyltransferase
Carnitine palmitoyltransferase 1 (CPT1) is one of the most significant enzymes in the metabolism of lipids. CPT1 is abundantly expressed in the brain and most organs and catalyzes the rate-limiting step in beta-oxidation. This enzyme couples an acyl-carnitine group with lipids and facilitates their transport across the outer mitochondrial membrane. CPT2 then removes the carnitine group from the lipid and allows its degradation via beta-oxidation. Blockage of CPT1 has been linked to therapeutic and preventative effects in the progression of multiple sclerosis.
Markholt, A.; Oklinski, M.; Larsen, A. et al. Pharmacological inhibition of carnitine palmitoyltransferase 1 inhibits and reverses experimental autoimmune encephalitis in rodents. PLOS ONE, 2020.