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Inhibitors of Sphingolipid Metabolism

Sphingolipids are able to exert cell signaling effects. Ceramide is a central component of sphingolipid metabolism that is tightly regulated due to its pro-apoptotic effect. Enzymes involved in the conversion of ceramide to other sphingolipids have been targeted in drug resistance by depleting ceramide to produce pro-survival sphingolipids. Sphingosine kinases, ceramidase, glucosylceramide synthase, and ceramide synthase are all enzymes involved in the metabolism of sphingolipids. Check out Avanti’s wide variety of sphingolipid metabolism inhibitors below!

Lewis, A.C., Wallington-Beddoe, C.T., Powell, J.A., et al. Targeting sphingolipid metabolism as an approach for combination therapies in hematological malignancies. Cell Death Discov. 4, 72 (2018). https://doi.org/10.1038/s41420-018-0075-0