Inhibitors of Autotaxin

Autotaxin (ATX) is an enzyme that makes extracellular lysophosphatidate (LPA) and lysophosphatidylcholine (LPC). ATX is involved in wound healing, inflammation, tumor growth, metastasis, and chemo-resistance. Understanding ATXs role in cell signaling and how it is regulated is important for several physiological and pathological conditions.

Benesch, M. G., Zhao, Y. Y., Curtis, J. M., McMullen, T. P., & Brindley, D. N. (2015). Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate. Journal of lipid research, 56(6), 1134–1144. https://doi.org/10.1194/jlr.M0...

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