Deuterated Bile Acids

Bile acids are potent digestive surfactants which promote the absorption of lipids. They also represent the primary pathway for cholesterol catabolism and account for approximately 50% of the daily turnover of cholesterol [2]. However, bile acids are no longer limited to solely that. Bile acids have now been recognized as hormones involved in the regulation of various metabolic processes. Bile acids regulate not only their own synthesis and enterohepatic circulation, but also triglyceride, cholesterol, glucose and energy homeostasis. Current metabolomic and lipidomic efforts aim to provide new insights into the mechanism of bile acid signaling in the regulation of lipid metabolism and the maintenance of lipid homeostasis. [1,2]

Avanti offers a comprehensive line of unlabeled and deuterated pure bile acids as a complement to primary, secondary, and/or conjugated bile acid research. Order our bile acids for use in any clinical, toxicological, or research laboratory.

[1] Qi Y, Jiang C, Cheng J, Krausz KW, Li T, Ferrell JM, Gonzalez FJ, Chiang JY. Bile acid signaling in lipid metabolism: metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice. Biochim Biophys Acta. 2015 Jan;1851(1):19-29. doi: 10.1016/j.bbalip.2014.04.008. Epub 2014 May 4. PMID: 24796972; PMCID: PMC4219936.

[2] Staels B, Fonseca VA. Bile acids and metabolic regulation: mechanisms and clinical responses to bile acid sequestration. Diabetes Care. 2009 Nov;32 Suppl 2(Suppl 2):S237-45. doi: 10.2337/dc09-S355. PMID: 19875558; PMCID: PMC2811459.