Product Spotlight: Fluorescent Lipids in Nanomedicine

Posted on March 04, 2021

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Nanomedicine: Using Fluorescent Lipids to Translate Laboratory Research to Clinical Use

Nanomedicine is one of the hottest trends in disease diagnostics, prevention, and treatment. Lipids are used extensively in nanosystems such as liposomes and solid lipid nanoparticles (SLNPs). These nanosystems are used in a variety of therapeutic fields such as anticancer therapies, antimicrobials, treatment of diseases of the central nervous system, and many other conditions. Treatments of diseases may also be enhanced via loading the drugs into a lipid-based nanosystem. One of the more well-known uses of lipid nanosystems arises from the current COVID-19 pandemic. Lipid nanoparticles are used to carry mRNA into cells and instruct them to make antigens and stimulate the production of antibodies to fight against the virus.

Research has been heavily focused on nanosystems due to their ability to improve stability and solubility of the cargo that they carry, promote transport across cellular membranes, and prolong circulation times to improve safety and efficacy. These promising attributes of lipid nanosystems led to a high projection for nanomedicines used in therapeutics. The number of nanomedicines available for therapeutic use in humans falls well below the projected number of nanomedicines that should be available.

Why is this the case? Such a promising area of medicine with a high level of interest from researchers all over the world should not be lagging behind projections, but they are. The primary reason for the failure of nanomedicines to meet projections is the inability to confirm their translational significance from lab to clinical use. This is due to the physicochemical properties of nanomedicines having a large influence on their biological properties. Fluorescent labels may affect the properties of nanomedicines. A greater understanding of how these fluorescent labels affect nanomedicines is imperative.

This is where Avanti’s Fluorescent Lipids make their grand appearance. Nanomedicines can be labeled with fluorescent lipids to probe their interference on the intrinsic behavior of cell bilayers. Recently, Avanti’s TopFluor-PC and Cy5-DSPE products were used to trace the fate of liposomal nanocarriers and compare the dye-labeled information with data obtained from non-labeled liposomes. Labeling lipids used in biological systems research is common. But the effects of the dye used to label these lipids are often overlooked and could lead to false positives or the discarding of a promising strategy due to a false-negative. A greater understanding of the effect that a dye can have on a lipid nanocarrier system could help alleviate these issues and lead to a greater rate of translation from laboratory research to clinical results. Click HERE to continue reading more about how Avanti’s fluorescent lipids are helping optimize new drug delivery systems!

Are you looking for fluorescent lipids to jump-start your lipid research? Look no further than Avanti! Avanti has a wide variety of fluorescent lipids for all of your research needs. We currently offer Fluorescent Phospholipids, Sphingolipids, Glycerolipids, Sterols, and several Others. These lipids have been prepared by adding various moieties with fluorescent properties and, as always, they have been prepared to meet the Avanti purity standard!