New Product Spotlight: MAG Products

Posted on June 02, 2020


In this month’s new product spotlight, we’re highlighting our monoacylglycerol (MAG) products and lipid mesophase crystallization. Keep reading for more information, and how to order!

MAGs and Lipid Cubic Phase

Lipid Cubic Phase (LCP), which forms spontaneously via self-assembly of many monoacylglycerol (MAG) species, has been found to improve the stablization and crystalization of integral membrane proteins - including G-protein receptors. The method has been shown to be quite versatile in that it has been used to solve X-ray crystallographic structures of prokaryotic and eukaryotic proteins, proteins that are monomeric, homo- and hetero-multimeric, chromophore-containing and chromophore-free, and alpha-helical and beta-barrel proteins.

More recently, cubic phase has also been proposed to be an effective drug release matrix and to occur in biological systems where they play a role in fat digestions and membrane fusion.

Avanti currently offers eight modified MAGs to use in meso crystallization studies, encapsulation of hydrophilic compound in the water channels, encapsulation of hydrophobic compounds within the lipid bilayer, encapsulation of amphilic compounds within the lipid-water interfacial environments, and/or evaluation in biological processes.

Interested in learning more about Avanti and our products? Click here for more information.

Reference:

Meikle TG, Keizer DW, Babon JJ, Drummond CJ, Separovic F, Conn CE, Yao S. Physiochemical Characterization and Stability of Lipidic Cubic Phases by Solution NMR. Langmuir. 2020 Jun 9;36(22):6254-6260. doi: 10.1021/acs.langmuir.0c00949. Epub 2020 Jun 1. PMID: 32418433.