Research Spotlight

Research Spotlight: Sex Differences in Insulin Sensitivity are Related to Muscle Tissue Acylcarnitine But Not Subcellular Lipid Distribution

Posted on April 26, 2021

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Our first May Research Spotlight uses Avanti's Lipidomic Standards to investigate lipid subspecies distribution as a contributor to differences in insulin sensitivity between men and women with obesity. Keep reading to check out the great work going on at University of Colorado Anschutz Medical Campus in Aurora, Colorado

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Research Spotlight: Investigating the Impact of Delivery System Design on the Efficacy of Self-Amplifying RNA Vaccines

Posted on April 12, 2021

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We hope you had a chance to read our most recent Lipid Leaders Interview with Dr. Yvonne Perrie. In the interview, Dr. Perrie gave us some great insight into her current research. To follow that, we wanted to share one of her recent publications investigating the impact of different delivery systems on the efficacy of self-amplifying mRNA (SAM) vaccines. Dr. Perrie and her team prepared and compared four different cationic SAM delivery platforms including liposomes, solid lipid nanoparticles (SLNs), polymeric nanoparticles (NPs), and emulsions. These lipid-based delivery platforms were prepared using Avanti’s DOTAP and DDA products. Keep reading to find out what this investigation uncovered!

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Research Spotlight: Lipopolymers and Lipids from Lung Surfactants in Association with N-acetyl-l-cysteine: Characterization and Cytotoxicity

Posted on March 30, 2021

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Our first April Research Spotlight comes from Nadia Chiaramoni. Nadia connected with us on Twitter and shared one of her recent works where she utilized our diacetylene lipids to form polymeric liposomes as a possible N-acetyl-I-cysteine (NAC) delivery system. Keep reading to check out Nadia’s publication in the Chemistry and Physics of Lipids journal and the great work that she is doing at the Universidad Nacional de Quilmes in Buenos Aires, Argentina.

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Research Spotlight: Deep Mining of Oxysterols and Cholestenoic Acids in Human Plasma and Cerebrospinal Fluid: Quantification using Isotope Dilution Mass Spectrometry

Posted on March 15, 2021

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Our second citation promotion for March comes from Dr. William Griffiths at Swansea University Medical School in Wales. Dr. Griffiths and his team of collaborators used Avanti’s oxysterolSPLASH and individual oxysterol standards to develop methodology to identify and quantify multiple sterols (oxysterols and sterol-acids) in plasma and cerebrospinal fluid. Avanti’s own, Lisa Connell, Director of the Lipidomics Division, is included as an author on the paper for her work in developing these standards. Keep reading to learn more about this exciting work!

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Research Spotlight: Mono- and Poly-unsaturated Phosphatidic Acid Regulates Distinct Steps of Regulated Exocytoses in Neuroendocrine Cells

Posted on February 16, 2021

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We would like to thank Nick Vitale from the Universite de Strasbourg in France for submitting this publication to the Citation Promotion Contest! Nick and his team are loyal customers of Avanti, and it’s exciting to see what they have been able to accomplish in the work titled “Mono- and Poly-Unsaturated Phosphatidic Acid Regulates Distinct Steps of Regulated Exocytoses in Neuroendocrine Cells.” Keep reading for more!

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Research Spotlight: Using Avanti LIPIDOMIX® Standards to Create Lipidomics Software

Posted on February 01, 2021

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As we continue our Citation Promotion series, check out how Jeremy Koelmel and his research team use Avanti LIPIDOMIX® Standards to create lipidomics software for the semi-quantification of lipids! They have released the LipidMatch Flow, LipidMatch Normalizer, and Lipid Annotator software platforms. Keep reading to find out how to access their software and how you can use it for analysis in your lipidomics research!

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Research Spotlight: Localization of Cyclopropane Modifications in Bacterial Lipids via 213 nm Ultraviolet Photodissociation Mass Spectrometry

Posted on January 21, 2021

Mass Spectrometry
Check out this exciting research submitted, as part of our Citation Promotion, by Molly Blevins from the Department of Chemistry, University of Texas at Austin! The work is titled “Localization of Cyclopropane Modifications in Bacterial Lipids via 213 nm Ultraviolet Photodissociation Mass Spectrometry”. Molly and the rest of the Brodbelt research group were able to employ 213 nm ultraviolet photodissociation mass spectrometry (UVPD-MS) for structural characterization of cyclopropane rings in bacterial phospholipids and mycolic acids.

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