Research Spotlight

Research Spotlight: Combinatorial Liposomal Peptide Vaccine Induces IgA and Confers Protection Against Influenza Virus and Bacterial Super-Infection

Posted on November 12, 2021


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3D-PHAD… sounds cool, right? Well, there’s more to this Avanti Lipid product than a cool name. Avanti’s PHAD is the first fully synthetic monophosphoryl lipid A (MPLA) available for use in human vaccines. But what does the 3D stand for? 3D means that this PHAD product is a 3-deacylated form of MPLA. Avanti’s PHAD products are great adjuvants for human vaccine applications due to their ability to elicit a strong immune response while also exhibiting a lower pyrogenic profile than the naturally occurring bacterial agent. Enough about this product’s name, keep reading to learn how it’s being used!

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Research Spotlight: A Potent Cancer Vaccine Adjuvant System for Particleization of Short, Synthetic CD8+ T Cell Epitopes

Posted on October 29, 2021


Graphical Abstract
To kill cancer cells, short-tumor-derived peptides (8-10 amino acids in length) must be recognized by the CD8+ T cell receptors. This promising method for killing cancer cells has not produced the desired results in clinical studies. Keep reading to learn how researchers at the University of Buffalo are working to improve this method!

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Research Spotlight: Prophylactic efficacy against Mycobacterium tuberculosis using ID93 and lipid-based adjuvant formulations in the mouse model

Posted on October 22, 2021


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Globally, tuberculosis, a treatable and preventable disease, kills 1.6 million people every year. A latent form of tuberculosis, Mycobacterium tuberculosis (Mtb), is estimated to infect nearly a quarter of the world’s total population. It is imperative that we as a scientific community find alternatives to the current TB vaccines being used today. Keep reading to learn more about a research team doing just that!

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Research Spotlight: An Improved and Highly Selective Fluorescence Assay for Measuring Phosphatidylserine Decarboxylase Activity

Posted on October 05, 2021


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Hopefully, you’ve had the opportunity to read our interview with Dr. Dennis Voelker. If you haven’t, SPOILER ALERT! In the interview, Dr. Voelker describes the significance that a recently developed fluorescence assay has in future diagnostic and therapeutic research. He says “The field of lipid biochemistry is ripe for expansion into the realm of screening for- and identifying- novel inhibitors of essential enzymes for application as new drugs for treating all types of microbial infections, including viruses, bacteria and fungi.” Keep reading to learn more about this highly selective fluorescence assay for measuring phosphatidylserine decarboxylase activity!

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Research Spotlight: World Brain Day!

Posted on July 07, 2021


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World Brain Day is July 22, 2021! Keep reading to learn about research, from one of our former lipid leaders, aimed at identifying metabolites that contribute to neurodegeneration resulting from Cerebrotendinous xanthomatosis (CTX)!

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Research Spotlight: 1-Stearoyl-2-docosahexaenoyl-phosphatidic acid interacts with and activates Praja-1, the E3 ubiquitin ligase acting on the serotonin transporter in the brain

Posted on July 07, 2021


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We hope you had a chance to read our most recent Lipid Leaders Interview with Dr. Fumio Sakane. To follow that great interview, we wanted to share one of his recent publications investigating the importance of lipid composition on the regulation of serotonin levels and how this contributes to the pathophysiology/therapeutics of various psychiatric disorders such as OCD, depression, autism, and schizophrenia. Keep reading to learn more!

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Research Spotlight: The Acyl Chains of Phosphoinositide PIP3 Alter the Structure and Function of Nuclear Receptor Steroidogenic Factor-1

Posted on June 23, 2021


Sf1 Crystal Structure
Nuclear receptor steroidogenic factor-1 (SF-1, NR5A1) specifically binds the signaling phosphoinositides, PI(4,5)P2 and PI(3,4,5)P3. Research has previously shown how the headgroups of these PIP lipids interact with and regulate SF-1 function. But what role do the acyl chains of these PIPs play in this interaction? Keep reading to see what researchers at Vanderbilt University School of Medicine found out.

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Research Spotlight: Cardiolipin-Induced Activation of Pyruvate Dehydrogenase Links Mitochondrial Lipid Biosynthesis to TCA Cycle Function

Posted on June 10, 2021


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Hopefully, you’ve had time to read our interview with Dr. Miriam Greenberg, but if you haven’t it’s a MUST read! If you’re wondering what type of research she has been engaged in recently, keep reading this review of an article she published in 2019 titled “Cardiolipin-Induced Activation of Pyruvate Dehydrogenase Links Mitochondrial Lipid Biosynthesis to TCA Cycle Function”

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Research Spotlight: C24:0 and C24:1 Sphingolipids in Cholesterol-Containing, Five- and Six-Component Lipid Membranes

Posted on May 12, 2021


Goni Publication
We hope you had a chance to read our most recent Lipid Leaders Interview with Dr. Felix Goni. In the interview, Dr. Goni gave us some great insight into his research at the University of the Basque Country and Instituto Biofisika. To follow that, we wanted to share one of his recent publications investigating C24:0 and C24:1 Sphingolipids in Cholesterol-Containing, Five- and Six-Component Lipid Membranes. Dr. Goni has been a loyal Avanti customer and friend for many years, and it is always exciting to see what his group accomplishes! Keep reading to learn more!

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Research Spotlight: Sex Differences in Insulin Sensitivity are Related to Muscle Tissue Acylcarnitine But Not Subcellular Lipid Distribution

Posted on April 26, 2021


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Our first May Research Spotlight uses Avanti's Lipidomic Standards to investigate lipid subspecies distribution as a contributor to differences in insulin sensitivity between men and women with obesity. Keep reading to check out the great work going on at University of Colorado Anschutz Medical Campus in Aurora, Colorado!

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Research Spotlight: Investigating the Impact of Delivery System Design on the Efficacy of Self-Amplifying RNA Vaccines

Posted on April 12, 2021


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We hope you had a chance to read our most recent Lipid Leaders Interview with Dr. Yvonne Perrie. In the interview, Dr. Perrie gave us some great insight into her current research. To follow that, we wanted to share one of her recent publications investigating the impact of different delivery systems on the efficacy of self-amplifying mRNA (SAM) vaccines. Dr. Perrie and her team prepared and compared four different cationic SAM delivery platforms including liposomes, solid lipid nanoparticles (SLNs), polymeric nanoparticles (NPs), and emulsions. These lipid-based delivery platforms were prepared using Avanti’s DOTAP and DDA products. Keep reading to find out what this investigation uncovered!

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Research Spotlight: Lipopolymers and Lipids from Lung Surfactants in Association with N-acetyl-l-cysteine: Characterization and Cytotoxicity

Posted on March 30, 2021


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Our first April Research Spotlight comes from Nadia Chiaramoni. Nadia connected with us on Twitter and shared one of her recent works where she utilized our diacetylene lipids to form polymeric liposomes as a possible N-acetyl-I-cysteine (NAC) delivery system. Keep reading to check out Nadia’s publication in the Chemistry and Physics of Lipids journal and the great work that she is doing at the Universidad Nacional de Quilmes in Buenos Aires, Argentina.

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Research Spotlight: Deep Mining of Oxysterols and Cholestenoic Acids in Human Plasma and Cerebrospinal Fluid: Quantification using Isotope Dilution Mass Spectrometry

Posted on March 15, 2021


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Our second citation promotion for March comes from Dr. William Griffiths at Swansea University Medical School in Wales. Dr. Griffiths and his team of collaborators used Avanti’s oxysterolSPLASH and individual oxysterol standards to develop methodology to identify and quantify multiple sterols (oxysterols and sterol-acids) in plasma and cerebrospinal fluid. Avanti’s own, Lisa Connell, Director of the Lipidomics Division, is included as an author on the paper for her work in developing these standards. Keep reading to learn more about this exciting work!

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Research Spotlight: Mono- and Poly-unsaturated Phosphatidic Acid Regulates Distinct Steps of Regulated Exocytoses in Neuroendocrine Cells

Posted on February 16, 2021


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We would like to thank Nick Vitale from the Universite de Strasbourg in France for submitting this publication to the Citation Promotion Contest! Nick and his team are loyal customers of Avanti, and it’s exciting to see what they have been able to accomplish in the work titled “Mono- and Poly-Unsaturated Phosphatidic Acid Regulates Distinct Steps of Regulated Exocytoses in Neuroendocrine Cells.” Keep reading for more!

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Research Spotlight: Using Avanti LIPIDOMIX® Standards to Create Lipidomics Software

Posted on February 01, 2021


Mass Spectrometry
As we continue our Citation Promotion series, check out how Jeremy Koelmel and his research team use Avanti LIPIDOMIX® Standards to create lipidomics software for the semi-quantification of lipids! They have released the LipidMatch Flow, LipidMatch Normalizer, and Lipid Annotator software platforms. Keep reading to find out how to access their software and how you can use it for analysis in your lipidomics research!

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Research Spotlight: Localization of Cyclopropane Modifications in Bacterial Lipids via 213 nm Ultraviolet Photodissociation Mass Spectrometry

Posted on January 21, 2021


Mass Spectrometry
Check out this exciting research submitted, as part of our Citation Promotion, by Molly Blevins from the Department of Chemistry, University of Texas at Austin! The work is titled “Localization of Cyclopropane Modifications in Bacterial Lipids via 213 nm Ultraviolet Photodissociation Mass Spectrometry”. Molly and the rest of the Brodbelt research group were able to employ 213 nm ultraviolet photodissociation mass spectrometry (UVPD-MS) for structural characterization of cyclopropane rings in bacterial phospholipids and mycolic acids.

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