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Product Spotlight

Attacking global pandemics, cancer, and rare diseases with lipid-based adjuvant systems

Posted on April 01, 2022

Adjuvant Product Spotlight April 2022
Vaccine research has been rapidly increasing since the early 1990s. Between 1993 and 1997, less than 20,000 papers and patents were published related to vaccines. Fast forward twenty years, between 2013 and 2017, nearly 90,000 papers and patents were published related to vaccines (Global Science and Technology Trends Report, CAS, n.d.). And with the recent COVID-19 pandemic and subsequent race to find a vaccine, these numbers are sure to soar even higher between 2018 and 2022. Avanti's primary role in the pandemic has been as a supplier of lipids for the lipid nanoparticle delivery system, but our lipid-based adjuvant systems are also being investigated for COVID-19 vaccines, as well as cancer treatments and rare virus vaccines. Read the full story by clicking the link!

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Positive Charge Leads to Positive Results: DOTAP and MC3 in Lipid-Polymer Hybrid Nanoparticles

Posted on February 28, 2022

Dotap Product Spotlight Square
mRNA therapeutics are being investigated for various diseases such as cancer immunotherapy, protein replacement, and infectious diseases. One of the key benefits of using mRNA compared to non-viral DNA or adeno-associated virus (AAV) gene delivery systems is that mRNA does not have to gain access to the nucleus to undergo transcription. This usually means that protein production is more robust and much faster. mRNA therapy also has a lower risk of mutagenesis and thus has a safer genotoxic profile. Many of our previous articles have described the challenges associated with protecting mRNA in extracellular environments. Lipids have emerged as a highly attractive delivery vehicle for mRNA.

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Product Spotlight: Oxysterols

Posted on February 09, 2022

Oxysterol Product Spotlight Square
Recently, Dr. William Griffiths along with his co-worker Dr. Yuqin Wang published a fascinating review of cholesterol metabolism in immunology. Keep reading to learn what has led to recent advancements and the role that oxysterols play in the immune system!

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Formulations Insights: Using Natural Sterol Alternatives to Replace Cholesterol in LNP Drug-Delivery Formulations

Posted on December 03, 2021

Sterol Lnp Formulations
If you’re trying to package, protect, and deliver genetic material to the inside of a cell, it is now common practice to use a lipid nanoparticle (LNP) delivery system. And who better to trust with your lipid delivery systems research than Avanti? With a quality standard that accepts nothing less than the best, Avanti’s lipid products are the best choice for preparing lipid delivery systems used in vaccine research. Keep reading to learn more!

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Product Spotlight: PHAD® Adjuvants

Posted on November 16, 2021

Phad Product Spotlight Image For Twitter
Avanti has you covered when it comes to lipid-based adjuvants. As you’ve seen in our research spotlights, our PHAD adjuvants can be used individually or in combination with other adjuvants to elicit stronger immune responses when compared to vaccines relying on an antigen alone. Regardless of which type of adjuvant(s) you choose for your vaccine research, you can rest assured that when you choose Avanti and Croda, you’re choosing safe and effective adjuvants. Let’s take a quick look at some of our lipid-based adjuvant products in the PHAD line.

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Product Spotlight: Photoswitchable AzoPC

Posted on October 16, 2021

Photoswitchable Lipids
Azobenzenes are prototypical molecular “switches” that exist in two distinct states – cis and trans. These states have different physical properties. The trans isomer is energetically preferred in solution but adding a source of energy can cause the azobenzene moiety to “switch” from trans to cis resulting in an on-and-off molecular switch. Keep reading to learn more about one such product from Avanti!

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Product Spotlight: Lipids for GUVs

Posted on June 16, 2021

Lnp Illustrations
Current events reinforce the importance of lipid-based delivery systems, and Avanti products are perfect for lipid-based particle formulations. Keep reading to learn about a special class of particles, Giant Unilamellar Vesicles (GUVs) and their interesting applications!

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Product Spotlight: Understanding the Role of Oxysterols in the Brain

Posted on May 12, 2021

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Oxysterols are an important class of regulatory lipids involved in a wide variety of biological functions. Oxysterols have huge potential in pharmaceutical applications due to their role in cholesterol metabolism, cell growth, and many other biological processes. Chances are slim that you won’t be able to find the oxysterol that you’re looking for on our website. And if you can’t, just contact us about custom synthesizing the oxysterol you need! Keep reading to find out how oxysterols are being used in Alzheimer’s disease and brain sterol homeostasis research right now!

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Product Spotlight: Exclusive Detergents

Posted on February 16, 2021

Protein Crystallography
Avanti is in no short supply of products to aid in your projects and applications. This month, we are taking a closer look at Avanti’s Exclusive Detergents for your protein crystallography research.

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New Product Spotlight: Detergents

Posted on May 12, 2020

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In this month’s New Product Spotlight, we’re highlighting our detergents! Keep reading for a list of some of Avanti’s unique detergents and how to utilize them in your research.

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Product Spotlight: Adjuvants

Posted on April 09, 2020

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Avanti is ready to support your adjuvant formulation development activities and continue working toward more effective adjuvants and adjuvant combinations to support global health strategies and prevent future pandemics. Keep reading for more information.

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New Product Spotlight: IsoPure

Posted on March 10, 2020

Iso Pure
Avanti Polar Lipids is excited to announce that IsoPure phospholipids are now available! Find out more about our new line of products, and what they can do for your research.

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Spotlight: Ceramide Delivery System

Posted on February 21, 2018

In addition to its role in cellular structure, the bioactive sphingolipid, ceramide, has been shown to be important for the regulation of a host of cellular functions including cell growth, proliferation, differentiation, senescence, necrosis, and apoptosis...

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Spotlight: Ceramide Synthase (CerS) Assay Kit

Posted on February 21, 2018

Ceramide synthases (CerSs) acylate sphingoid long-chain bases to form (dihydro)ceramides [1]. Mammals contain six distinct CerSs, each of which uses a specific subset of fatty acyl-coenzyme As to produce various subspecies of (dihydro)ceramides...

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Spotlight: pacFA Ceramide

Posted on February 21, 2018

Dr. Erhard Bieberich's laboratory at Georgia Reagents University is interested in proteins that mediate the regulation of cilia and flagella by ceramide. Flagella and cilia are sensory and motor cellular organelle responsible for moving extracellular fluids and particles and propelling cells and unicellular organisms...

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Spotlight: MVL5/GMO Delivery System for siRNA/DNA

Posted on February 21, 2018

The therapeutic promise of gene therapy in treating and altering disease states has provided significant motivation in developing improved methods to deliver genes to cells [1,2]. Currently, two major classes of gene delivery vectors exist: viral and synthetic...

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