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In addition to its role in cellular structure, the bioactive sphingolipid, ceramide, has been shown to be important for the regulation of a host of cellular functions including cell growth, proliferation, differentiation, senescence, necrosis, and apoptosis...
Ceramide synthases (CerSs) acylate sphingoid long-chain bases to form (dihydro)ceramides [1]. Mammals contain six distinct CerSs, each of which uses a specific subset of fatty acyl-coenzyme As to produce various subspecies of (dihydro)ceramides...
Dr. Erhard Bieberich's laboratory at Georgia Reagents University is interested in proteins that mediate the regulation of cilia and flagella by ceramide. Flagella and cilia are sensory and motor cellular organelle responsible for moving extracellular fluids and particles and propelling cells and unicellular organisms...
On February 27- March 2, 2016, The Avanti Roadshow will be at the 60th Annual Biophysical Society Meeting in Los Angeles, CA! Year after year, the Biophysical Society Meeting is a great place that brings together some of the leading scientists from around the world. With over 7,000 attendees and 500 speakers, Avanti loves this meeting because it still maintains the “small meeting” feel. It is a great place for learning and networking.
The proatherogenic properties of the cholesterol 5,6-secosterols (atheronal-A and atheronal-B), recently discovered in atherosclerotic arteries, have been investigated in terms of their effects on monocyte/macrophage function. A fluorescent analogue of atheronal-B, when cultured in either aqueous buffer or in media containing fetal calf serum, is rapidly taken-up into cultured macrophage cells and accumulates at perinuclear sites...
The therapeutic promise of gene therapy in treating and altering disease states has provided significant motivation in developing improved methods to deliver genes to cells [1,2]. Currently, two major classes of gene delivery vectors exist: viral and synthetic...
Avanti’s new Fluorescent Endocannabinoids may be used to map the impact of various treatments and inhibitors on endocannabinoid uptake and distribution in living cells.
PAHSA levels correlate highly with insulin sensitivity and are reduced in adipose tissue and serum of insulin-resistant humans. In adipocytes, PAHSAs signal through GPR120 to enhance insulin-stimulated glucose uptake. Thus, FAHFAs are endogenous lipids with the potential to treat type 2 diabetes.
Dr. Di Bush gave a presentation at CRS in Seattle, Washington. Her presentation covered the selection, preparation and application of liposomes. To see her full presentation click the link below.
Whether you are looking for phospholipids, sphingolipids, sterols, or any other of our numerous product offerings, Avanti’s research products are the highest purity lipids on the market and give you the best possibility for success.
Researchers from Northwest University (Xi’an, Shaanxi, China) used numerous lipid analytical standards from Avanti in a serum lipidomic analysis using UPLC-QTOF/HDMS to study lipid metabolism in chronic kidney disease (CKD). This interesting work identifies profound changes in lipid metabolites in individuals with CKD...
People do Amazing Things with Our Lipids! Researchers from the National Center for Global Health and Medicine (Tokyo, Japan) are studying the role of PAF signaling in neuropathic pain, a chronic pain condition resulting from injury of the peripheral or central nervous systems. PAF, as well as, ATP and lyophosphatidic acid are thought to be central mediators of neuropathic pain.
