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Manufacturing

Kilo Labs

Avanti’s many cGMP Kilo Labs ensure the successful transition to larger scale synthesis essential for quality API production. You may be assured knowing that your Clinical Studies have the backing of Avanti quality.

Equipment

  • 8 manufacturing suites equipped with 8 ft walk-in hoods
  • 3 solvent removal and drying suites
  • 2 – 316SS reactors (20L and 80L capacity) with process temperature control to 100°C
  • 2 – 316SS reaction vessels (20L capacity)
  • 4 – 316SS high-viscosity mixer/reactor (2 x 130L, 22L and 5L capacity) with process temperature control to 100°C
  • 316SS Nutsche filter (140L capacity) with process temperature control from -75 to 200°C
  • Multiple glass reactors, up to 100L capacity, with process temperature control from -50 to 200°C
  • 4 Buchi R-220 SE rotary evaporators (volume range: up to 20L Capacity)
  • each equipped with recirculating chiller and vacuum controller
  • 2 Heidolph rotary evaporators (volume range: up to 3L Capacity) each equipped with recirculating chiller
    and vacuum controller
  • 2 FTS Dura-Dry MP Freeze-Dryer (20L capacity)
  • 5 VirTis Freezemobile 35EL freeze dryer (20L capacity)
  • 3 FTS Dura-Top Bulk Tray Dryer (5 shelf) with computer control
  • 3 Yamato DP-61 Vacuum Oven (7.5cf capacity)
  • 10 Yamato DP-63 Vacuum Oven (7.5cf capacity)
  • 20cf Vee Blender, 316SS
  • 7cf Blend Vessel, 316SS
  • 3 Walk-in freezers, each with a capacity of 1000cf at -20°C
  • Warehouse and storage
  • Associated reaction glassware and work-up equipment

Chromatography

Avanti specializes in high purity Chromatographic separation of hydrophobic compounds. Our Laboratory scale medium pressure flash chromatography will readily translate to cGMP production in the Kilo Lab.

Equipment

  • 4 – chromatography suites equipped with semi-automated process HPLC systems
  • for multi-kilo scale purification, up to 1200mL/min
  • 4 – 6″ x 48″ 316SS HPLC Columns
  • 2 – 4″ x 40″ 316SS HPLC Columns
  • 8 – 6″ x 35″ Glass Low Pressure Static Columns
  • Buchi C-660 Fraction Collector
  • Assorted 1″, 1.5″, 2″, 3″ and 4″ diameter glass columns of various lengths