Standards for Lipidomics

Product Spotlight: OxysterolSPLASH™ LIPIDOMIX® Quantitative Mass Spec Internal Standard Mixture

Posted on November 01, 2019 |


Oxysterols are oxygenated cholesterol molecules that have distinct cell-signaling properties. They are inhibitors of SREBP-2 (sterol response element binding protein-2), which affects cholesterol biosynthesis. Oxysterols are also ligands for the liver X receptors, which regulates cholesterol, glucose and fatty acid homeostasis, allosteric modulators of the NMDA (N-methyl-D-aspartate) receptor, and serve as ligands for proteins within the Hedgehog signaling pathway. Research has shown that the oxysterols may play roles in multiple human pathologies, including ALS; Huntington’s, Alzheimer’s, and Parkinson’s diseases; and some forms of cancer. For a general or a comprehensive review, see Biochemical Society Transactions (2019) 47, 517-526 or Physiological Reviews (2000), 80(1) 361-554, respectively.

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