Critical Micelle Concentrations (CMCs)
|
|
Lipid
|
CMC (mM)
|
|
5:0 PC
|
90
|
|
6:0 PC
|
15
|
|
7:0 PC
|
1.4
|
|
8:0 PC
|
0.27
|
|
9:0 PC
|
0.029
|
|
10:0 PC
|
0.005
|
|
12:0 PC
|
90 nM
|
|
14:0 PC
|
6 nM
|
|
16:0 PC
|
0.46 nM
|
|
8:0 PG
|
1.21
|
|
10:0 PG
|
0.42
|
|
12:0 PG
|
0.13
|
|
14:0 PG
|
0.011
|
| 4:0 PS (5mM Ca2+)† |
4 |
| 5:0 PS (5mM Ca2+)† |
2 |
| 6:0 PS (5mM Ca2+)† |
1.2 |
| 7:0 PS (5mM Ca2+)† |
0.8 |
| 8:0 PS (5mM Ca2+)† |
0.4 |
|
8:0 PS
|
2.282
|
|
10:0 PS
|
0.096
|
|
8:0 Lyso PC
|
60
|
|
10:0 Lyso PC
|
6-8
|
|
12:0 Lyso PC
|
0.4-0.9
|
|
14:0 Lyso PC
|
0.043-0.090
|
|
16:0 Lyso PC
|
4-8.3 µM
|
|
18:0 Lyso PC
|
0.4 µM
|
|
|
|
|
Lipid Acronyms
|
|
PC
|
phosphatidylcholine
|
|
PG
|
phosphatidylglycerol
|
|
PS
|
phosphatidylserine
|
 |
Critical Micelle Concentrations
The critical micelle concentration (CMC) can be approximately defined as the lipid monomer concentration at which appreciable amounts (>5% of total) of micellar aggregates first begin to appear in the equilibrium:
nM1<=>Mn
|
CMC’s where determined in house by using a Pyrene Fluorescence technique or where obtained from the literature. Many of the literature values were confirmed by our in-house method.
† Data provided by Dr. Rinku Majumder, Department of Biochemistry, The University of North Carolina - Chapel Hill.
The method is generally outlined by:
http://turmac13.chem.columbia.edu/PDF_db/publications_301_350/340.pdf
References:
Handbook of Lipid Bilayers
by Derek Marsh.
ISBN 0849332559
CRC Press, Inc.
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