Miscibility of Phospholipid Binary Mixtures
|
|
Component 1
|
Component 2
|
Delta Tc
|
Miscibility
|
|
Phosphatidylcholine:Phosphatidylcholine Mixtures
|
|
12:0 PC
|
16:0 PC
|
43
|
L
|
|
12:0 PC
|
18:0 PC
|
57
|
VL
|
|
14:0 PC
|
16:0 PC
|
17
|
H
|
|
14:0 PC
|
18:0 PC
|
31
|
L-M
|
|
14:0 PC
|
20:0 PC
|
42
|
VL
|
|
16:0 PC
|
18:0 PC
|
14
|
H
|
|
18:1cdelta9PC
|
14:0 PC
|
40
|
VL
|
|
18:1cdelta9PC
|
16:0 PC
|
57
|
VL
|
|
18:1cdelta9PC
|
18:0 PC
|
71
|
VL
|
|
18:1cdelta9PC
|
22:0 PC
|
91
|
VL
|
|
18:1tdelta9PC
|
14:0 PC
|
11
|
L-M
|
|
18:1tdelta9PC
|
16:0 PC
|
28
|
L-M
|
|
18:1tdelta9PC
|
18:0 PC
|
42
|
L
|
|
16:0/18:1cdelta9PC
|
16:0 PC
|
44
|
VL
|
|
16:0/18:1cdelta9PC
|
16:0 PC
|
35
|
VL
|
|
16:0/22:6cccccc PC
|
16:0 PC
|
~70
|
VL
|
|
Phosphatidylcholine:Phosphatidylglycerol Mixtures
|
|
12:0 PC
|
12:0 PG•Na
|
~0
|
P
|
|
12:0 PC
|
12:0 PG•½Ca
|
~75
|
H
|
|
12:0 PC
|
14:0 PG•Na
|
25
|
M-H
|
|
12:0 PC
|
14:0 PG•½Ca
|
~87
|
M
|
|
12:0 PC
|
16:0 PG•Na
|
43
|
M
|
|
12:0 PC
|
16:0 PG•½Ca
|
~93
|
L
|
|
14:0 PC
|
14:0 PG•Na
|
0
|
H-P
|
|
14:0 PC
|
14:0 PG•½Mg
|
~51
|
H
|
|
14:0 PC
|
14:0 PG•½Ca
|
~61
|
H
|
|
14:0 PC
|
16:0 PG•Na
|
17
|
H
|
|
14:0 PC
|
16:0 PG•½Ca
|
~67
|
L-M
|
|
16:0 PC
|
14:0 PG•Na
|
18
|
H
|
|
16:0 PC
|
14:0 PG•½Ca
|
44
|
H
|
|
16:0 PC
|
16:0 PG•Na
|
0
|
P
|
|
16:0 PC
|
16:0 PG•½Ca
|
~50
|
H
|
|
18:0 PC
|
14:0 PG•Na
|
32
|
M
|
|
18:0 PC
|
16:0 PG•Na
|
14
|
H
|
|
18:0 PC
|
18:1cdelta9PG•½Ca
|
~70
|
VL
|
|
18:0 PC
|
18:1tdelta9PG•Na
|
45
|
L,complex
|
|
18:1cdelta9PC
|
16:0 PG•Na
|
59
|
VL
|
|
18:1cdelta9PC
|
16:0 PG•½Ca
|
107
|
VL
|
|
18:1cdelta9PC
|
18:1cdelta9PG•Na
|
~0
|
P
|
|
18:1cdelta9PC
|
18:1cdelta9PG•½Ca
|
~0
|
H
|
|
Phosphatidylcholine:Phosphatidylethanolamine Mixtures
|
|
14:0 PC
|
14:0 PE
|
24
|
M
|
|
14:0 PC
|
16:0 PE
|
~39
|
M
|
|
14:0 PC
|
16:1cdelta9PE
|
60
|
VL
|
|
14:0 PC
|
18:1cdelta9PE
|
38
|
VL
|
|
16:0 PC
|
16:0 PE
|
22
|
H
|
|
16:0 PC
|
16:1cdelta9PE
|
78
|
VL
|
|
16:0 PC
|
18:1cdelta9PE
|
57
|
VL
|
|
18:0 PC
|
14:0 PE
|
6
|
M-H
|
|
16:1cdelta9PC
|
14:0 PE
|
84
|
VL
|
|
18:1cdelta9PC
|
14:0 PE
|
65
|
VL
|
|
18:1cdelta9PC
|
16:0 PE
|
79
|
VL
|
|
18:1tdelta9PC
|
16:0 PE
|
50
|
VL(Fluid immiscibility)
|
|
Phosphatidylcholine:Phosphatidic Acid Mixtures
|
|
14:0 PC
|
14:0 PA•NaH
|
26
|
M
|
|
14:0 PC
|
14:0 PA•Ca
|
|
L-M
|
|
16:0 PC
|
16:0 PA•NaH
|
25
|
M
|
|
16:0 PC
|
16:0 PA•Ca,ph
|
6
|
No transition <70°
|
|
16:0 PC
|
16:0 PA•Ca,ph
|
8
|
VL-L
|
|
16:0 PC
|
16:0 PA:H2
|
21
|
M-H
|
|
Phosphatidylcholine:Phosphatidylserine Mixtures
|
|
14:0 PC
|
14:0 PS•Na
|
15
|
L
|
|
14:0 PC
|
14:0 PS•Ca
|
|
L
|
|
14:0 PC
|
16:0 PS•Na
|
29
|
M-H;complex
|
|
14:0 PC
|
18:1cdelta9PS•Na
|
~35
|
L-M
|
|
14:0 PC
|
18:1cdelta9PS•Ca
|
|
VL
|
|
18:0 PC
|
18:1cdelta9PS•Na
|
65
|
VL
|
|
18:1cdelta9PC
|
14:0 PS•Na
|
58
|
VL
|
|
Miscellaneous Phospholipid Mixtures
|
|
16:0 PE
|
18:1cdelta9PE
|
76
|
VL
|
|
14:0 PG•Na
|
16:0 PG•Na
|
18
|
H
|
|
16:0 PE
|
18:1tdelta9PG•Na
|
51
|
L
|
|
18:1cdelta9PE
|
16:0 PG•Na
|
63
|
L-M,complex
|
|
18:1cdelta9PE
|
14:0 PS•Na
|
53
|
L
|
|
18:1tdelta9PE
|
18:1cdelta9PS•Na
|
45
|
L
|
| P=Perfect |
Ideal mixing and no broadening of the phase transition in the mixture.
|
| H=High |
Mixing ideal or very nearly so; phase transitions of mixture are markedly broader than those of the pure components.
|
| M=Moderate |
Phase diagram deviates markedly from ideal behavior, but the solidus curve is not flat over any significant range of compositions.
|
| L=Low |
Solidus curve in phase diagam is essentially flat over some range of compositions encompassing a region 20-50% wide over the XB-axis.
|
| VL=Very Low |
Solidus curve is essentially flat over most of the range of compositions (along >50% of the XB-axis).
|
- Thermotropic Phase Transitions of Pure Lipids in Model Membranes and Their Modifications by Membrane Proteins, Dr. John R. Silvius, Lipid-Protein Interactions, John Wiley & Sons, Inc., New York, 1982, reprinted with permission from John Wiley & Sons, Inc.
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