999994C - 1,2-di-0-dodecyl-<EM>sn</EM>-glycero-3-phosphocholine - Avanti Polar Lipids
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MATERIAL SAFETY DATA SHEET

1,2-di-0-dodecyl-sn-glycero-3-phosphocholine
(Chloroform Solution)
1. Product Identification
Product Name:1,2-di-0-dodecyl-sn-glycero-3-phosphocholine
Physical Form: Chloroform Solution
Color:Clear Colorless Solution
Synonyms:12:0 Diether PC
M.W.:593.859
Chemical Formula: C32H68NO6P
Catalog Number: 999994C
Chemical Abstracts Registry Number: 72593-72-7
Emergency Contact Information:
24 Hour Emergency Telephone
CHEMTREC
United States: 1-800-424-9300
International: 703-527-3887

2. Composition/Information on Ingredients
Ingredient
CAS No
Percent
Hazardous
Chloroform
67-66-3
98-100%
Yes
Ethyl Alcohol
64-17-5
0-1%
Yes
1,2-di-0-dodecyl-sn-glycero-3-phosphocholine
 
72593-72-7
<1%
No

3. Hazards Identification

Emergency Overview
--------------------------
DANGER! MAY BE FATAL IF SWALLOWED, INHALED OR ABSORBED THROUGH SKIN. CAUSES IRRITATION TO SKIN, EYES AND RESPIRATORY TRACT. MAY AFFECT CENTRAL NERVOUS SYSTEM, CARDIOVASCULAR SYSTEM, LIVER AND KIDNEYS. SUSPECT CANCER HAZARD. MAY CAUSE CANCER. Risk of cancer depends on level and duration of exposure.
-----------------------------------------------------------
Potential Health Effects
----------------------------------

Inhalation:
Acts as a relatively potent anesthetic. Irritates respiratory tract and causes central nervous system effects, including headache, drowsiness, dizziness. Exposure to higher concentrations may result in unconsciousness and even death. May cause liver injury and blood disorders. Prolonged exposure may lead to death due to irregular heart beat and kidney and liver disorders.

Ingestion:

Causes severe burning in mouth and throat, pain in the chest and vomiting. Large quantities may cause symptoms similar to inhalation.

Skin Contact:

Causes skin irritation resulting in redness and pain. Removes natural oils. May be absorbed through skin.

Eye Contact:

Vapors cause pain and irritation to eyes. Splashes may cause severe irritation and possible eye damage.

Chronic Exposure:

Prolonged or repeated exposure to vapors may cause damage to the nervous system, the heart and the liver and kidneys. Contact with liquid has defatting effect and may cause chronic irritation of skin with cracking and drying and corresponding dermatitis. Chloroform is a suspected human carcinogen.

Aggravation of Pre-existing Conditions:

Persons with pre-existing skin disorders or eye problems, or impaired liver, kidney or respiratory function may be more susceptible to the effects of the substance.


4. First Aid Measures

Inhalation:
Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical attention.

Ingestion:

If swallowed, DO NOT INDUCE VOMITING. Give large quantities of water. Never give anything by mouth to an unconscious person. Get medical attention immediately.

Skin Contact:

Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical attention immediately. Wash clothing before reuse. Thoroughly clean shoes before reuse.

Eye Contact:

Immediately flush eyes with plenty of water for at least 15 minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.

Note to Physician:
Because kidney and liver effects may be delayed, keep victim under observation for 24 to 48 hours. Administration of fluids may help to prevent kidney failure. Obtain blood glucose, urinalysis, liver function tests, chest x-ray, and monitor cardiac function and fluid/electrolyte status. Monitor liver and kidney function for 4 to 5 days after exposure. Disulfiram, its metabolites, and a high carbohydrate diet appear to protect somewhat against chloroform toxicity. Do not give adrenalin! Tests may show increased bilirubin, ketosis, lowered blood prothrombin, and fibrinogen.


5. Fire Fighting Measures

Fire:
Slight fire hazard when exposed to high heat; otherwise, practically not flammable.

Explosion:
Sealed containers may rupture when heated.

Fire Extinguishing Media:

Use any means suitable for extinguishing surrounding fire.

Special Information:

In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode.


6. Accidental Release Measures

Ventilate area of leak or spill. Wear appropriate personal protective equipment as specified in Section 8. Isolate hazard area. Keep unnecessary and unprotected personnel from entering. Contain and recover liquid when possible. Collect liquid in an appropriate container or absorb with an inert material (e. g., vermiculite, dry sand, earth), and place in a chemical waste container. Do not use combustible materials, such as saw dust. Do not flush to sewer! US Regulations (CERCLA) require reporting spills and releases to soil, water, and air in excess of reportable quantities. The toll free number for the US Coast Guard National Response Center is (800) 424-8802.



7. Handling and Storage

Keep in a tightly closed light-resistant container, stored in a cool, dry, ventilated area. Protect against physical damage. Isolate from incompatible substances. Wear special protective equipment (Sec. 8) for maintenance break-in or where exposures may exceed established exposure levels. Wash hands, face, forearms, and neck when exiting restricted areas. Shower, dispose of outer clothing, change to clean garments at the end of the day. Avoid cross-contamination of street clothes. Wash hands before eating and do not eat, drink, or smoke in workplace. Containers of this material may be hazardous when empty since they retain product residues (vapors, liquid); observe all warnings and precautions listed for the product. Chloroform odor threshold: 250 mg/m3. The odor threshold only serves as a warning of exposure; not smelling it does not mean you are not being exposed.


8.
Exposure Controls/Personal Protection

Airborne Exposure Limits:
Chloroform:
-OSHA Permissible Exposure Limit (PEL):
50 ppm (TWA) Ceiling
-ACGIH Threshold Limit Value (TLV):
10 ppm (TWA), Listed as A3 animal carcinogen

Ventilation System:

A system of local and/or general exhaust is recommended to keep employee exposures below the Airborne Exposure Limits. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source, preventing dispersion of it into the general work area. Please refer to the ACGIH document, Industrial Ventilation, A Manual of Recommended Practices, most recent edition, for details.

Personal Respirators (NIOSH Approved):

If the exposure limit is exceeded and engineering controls are not feasible, wear a supplied air, full-facepiece respirator, airlined hood, or full-facepiece self-contained breathing apparatus. Breathing air quality must meet the requirements of the OSHA respiratory protection standard (29CFR1910.134). This substance has poor warning properties.

Skin Protection:

Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact.

Eye Protection:

Use chemical safety goggles and/or a full face shield where splashing is possible. Maintain eye wash fountain and quick-drench facilities in work area.


9. Physical and Chemical Properties

Appearance:
Clear Colorless Solution

Odor:

Characteristic ethereal odor.

Solubility:

0.8g/100g water @ 20C (68F).

Specific Gravity:

1.48 @ 20C/4C

pH:

No information found.

% Volatiles by volume @ 21C (70F):

100

Boiling Point:

62C (144F)

Melting Point:

-63.5C (-83F)

Vapor Density (Air=1):

4.1

Vapor Pressure (mm Hg):

160 @ 20C (68F)

Evaporation Rate (BuAc=1):

11.6


10. Stability and Reactivity

Stability:
Stable under ordinary conditions of use and storage. pH decreases on prolonged exposure to light and air due to formation of HCl.

Hazardous Decomposition Products:

May produce carbon monoxide, carbon dioxide, hydrogen chloride and phosgene when heated to decomposition.

Hazardous Polymerization:

Will not occur.

Incompatibilities:

Strong bases, alkali metals, fluorine, dinitrogen tetraoxide, potassium tert-butoxide, powdered aluminum, nitrogen tetroxide, powdered magnesium, disilane, sodium methylate, triisopropylphosphine.

Conditions to Avoid:
Light, heat, air and incompatibles.


11. Toxicological Information

Toxicological Data:
Chloroform: oral rat LD50: 908 mg/kg; skin rabbit LD50: > 20 gm/kg; inhalation rat LC50: 47702 mg/m3/4H; irritation data: skin rabbit 10 mg/24H open mild; eye rabbit: 20 mg/24H moderate; investigated as a tumorigen, mutagen, reproductive effector.

Reproductive Toxicity:

Birth defects have been seen in rats and mice exposed by inhalation of chloroform at concentrations greater than 00 ppm in air. Ingestion of chloroform by pregnant laboratory animals has resulted in fetotoxicity but not birth defects, and only at levels causing severe maternal effects.

Cancer Lists ----------------------------------------------------------------------------------------------------
 
--------------------NTP Carcinogen--------------------
Ingredient
Known
Anticipated
IARC Category
Chloroform (67-66-3)  
No
Yes
2B
Ethyl Alcohol (64-17-5)  
No
No
None
       


12. Ecological Information

Environmental Fate:
When released into the soil, this material is expected to leach into groundwater. When released into the soil, this material is expected to quickly evaporate. When released to water, this material is expected to quickly evaporate. When released into the water, this material is expected to have a half-life between 1 and 10 days. This material has a log octanol-water partition coefficient of less than 3.0. This material is not expected to significantly bioaccumulate. When released into the air, this material may be moderately degraded by reaction with photochemically produced hydroxyl radicals. When released into the air, this material may be moderately degraded by photolysis. When released into the air, this material may be removed from the atmosphere to a moderate extent by wet deposition. When released into the air, this material is expected to have a half-life of greater than 30 days.

Environmental Toxicity:

This material is not expected to be toxic to aquatic life. The LC50/96-hour values for fish are over 100 mg/l.


13. Disposal Considerations

Whatever cannot be saved for recovery or recycling should be handled as hazardous waste and sent to an RCRA approved waste facility. Processing, use, or contamination of this product may change the waste management options. State and local disposal regulations may differ from federal disposal regulations. Dispose of container and unused contents in accordance with federal, state, and local requirements.


14. Transport Information

Domestic (Land, D.O.T.)
-----------------------
Proper Shipping Name: RQ, CHLOROFORM

Hazard Class:
6.1

UN/NA:
UN1888

Packing Group: III

Information reported for product/size:
52L

International (Water, I.M.O.)
-----------------------------
Proper Shipping Name: CHLOROFORM

Hazard Class:
6.1

UN/NA:
UN1888
Packing Group: III

Information reported for product/size:
52L


15. Regulatory Information

--------\Chemical Inventory Status - Part 1\---------------------------
Ingredient 
TSCA
EC
Japan
Australia
Chloroform (67-66-3) 
Yes
Yes
Yes
Yes
Ethyl Alcohol (64-17-5) 
Yes
Yes
Yes
Yes

--------\Chemical Inventory Status - Part 2\---------------------------
Ingredient 
Korea
DSL
NDSL
Phil.
Chloroform (67-66-3) 
Yes
Yes
No
Yes
Ethyl Alcohol (64-17-5) 
Yes
Yes
No
Yes

-----\Federal, State & International Regulations - Part 1\-------------
 
-----SARA 302------
---------------SARA 313--------------
Ingredient
RQ
TPQ
List
Chemical Catg.
Chloroform (67-66-3)
10
10000
Yes
No
Ethyl Alcohol (64-17-5)
No
No
No
No

---\Federal, State & International Regulations - Part 2\---------------
   
RCRA
TSCA
Ingredient
CERCLA
261.33
8(d)
Chloroform (67-66-3)
10
U044
No
Ethyl Alcohol (64-17-5) 
No
No
No

   
Chemical Weapons Convention:  No
TSCA 12(b):  No
CDTA:  No
SARA 311/312:  Acute: Yes
Chronic: Yes 
Fire: No 
Pressure: No
Reactivity: No
(Mixture / Liquid)

WARNING:
THIS PRODUCT CONTAINS A CHEMICAL(S) KNOWN TO THE STATE OF CALIFORNIA TO CAUSE CANCER.

Australian Hazchem Code: 2Z

Poison Schedule:
S6

WHMIS:

This MSDS has been prepared according to the hazard criteria of the Controlled Products Regulations (CPR), and the MSDS contains all of the information required by the CPR.


16. Other Information

NFPA Ratings: Health: 2 Flammability: 0 Reactivity: 0

Label Hazard Warning:

DANGER! MAY BE FATAL IF SWALLOWED, INHALED, OR ABSORBED THROUGH SKIN. CAUSES IRRITATION TO SKIN, EYES, AND RESPIRATORY TRACT. MAY AFFECT CENTRAL NERVOUS SYSTEM, CARDIOVASCULAR SYSTEM, LIVER AND KIDNEYS. SUSPECT CANCER HAZARD. MAY CAUSE CANCER. Risk of cancer depends on level and duration of exposure.
Label Precautions:
Do not breathe vapor.
Do not get in eyes, on skin, or on clothing.
Keep container closed.
Use only with adequate ventilation.
Wash thoroughly after handling.

Label First Aid:

In case of contact, immediately flush eyes or skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. If inhaled, remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. If swallowed, DO NOT INDUCE VOMITING. Give large quantities of water. Never give anything by mouth to an unconscious person. In all cases get medical attention immediately.

Product Use:

Laboratory Reagent.

Revision Information:

No Changes.

Disclaimer:


Avanti Polar Lipids, Inc. provides the information contained herein in good faith but makes no representation as to its comprehensiveness or accuracy. This document is intended only as a guide to the appropriate precautionary handling of the material by a properly trained person using this product. Individuals receiving the information must exercise their independent judgment in determining its appropriateness for a particular purpose. AVANTI POLAR LIPIDS, INC. MAKES NO REPRESENTATIONS OR WARRANTIES, EITHER EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE WITH RESPECT TO THE INFORMATION SET FORTH HEREIN OR THE PRODUCT TO WHICH THE INFORMATION REFERS. ACCORDINGLY, AVANTI POLAR LIPIDS, INC. WILL NOT BE RESPONSIBLE FOR DAMAGES RESULTING FROM USE OF OR RELIANCE UPON THIS INFORMATION.


 

700 INDUSTRIAL PARK DRIVE, ALABASTER, AL 35007-9105
FAX: 800-229-1004 (USA & CANADA) OR 205-663-0756 (INT)
TELEPHONE: 800-227-0651 (US & CANADA) OR 205-663-2494 (INT)
info@avantilipids.com . www.avantilipids.com


Revised: 1/2014